Alcoholic Extract of Ashwagandha Leaves Protects Against Amnesia by Regulation of Arc Function

Molecular Neurobiology
Akash GautamMahendra K Thakur

Abstract

Our earlier report on scopolamine-induced amnesia and its improvement by pre-treatment with i-Extract (alcoholic extract of Ashwagandha leaf) suggested that the i-Extract mediated nootropic effect may involve neuronal immediate early gene, Arc. With a hypothesis that the i-Extract induced expression of Arc protein may cause augmentation in Arc function, we examined the effect of i-extract on a major function of Arc protein, i.e. F-actin expansion, using Arc antisense oligodeoxynucleotides (ODN). Stereotaxic infusion of Arc antisense ODN in the CA1 region of hippocampus decreased the level of Arc protein as demonstrated by immunoblotting. However, this decrease was attenuated when treated with i-Extract prior to infusion of Arc antisense ODN. We noted a significant decrease in the polymerization of F-actin during scopolamine-induced amnesia as well as Arc antisense ODN infusion that was restored rather enhanced when pre-treated with i-Extract in both the cases. We also compared the corresponding changes between CA1 (the infusion site) and CA3 (neighbouring site of infusion) regions of hippocampus, and found more pronounced effects in CA1 than in the CA3 region. The extent of F-actin polymerization, as revealed by changes in the ...Continue Reading

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Citations

Sep 13, 2015·Neurochemistry International·Renu WadhwaSunil C Kaul
Apr 28, 2017·Hippocampus·Meghraj Singh Baghel, Mahendra Kumar Thakur
Dec 8, 2020·Neurochemistry International·Padmanabh SinghM K Thakur
Feb 23, 2020·Neuroscience·M C Vishnu Shandilya, Akash Gautam

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