Alcoholic hepatomegaly: accumulation of protein in the liver

Science
E BaraonaC S Lieber

Abstract

The hepatomegaly that appears after long-term feeding of ethanol results in accumulation of protein that is quantitatively as important as the increase in lipid. The bulk of protein accumulated in the soluble fraction of the cell. Hepatic albumin and transferrin concentrations increase and colchicine-binding protein decreases, thus suggesting an intrahepatic retention of export proteins.

References

Jul 1, 1975·The Journal of Cell Biology·C M RedmanG E Palade
Dec 1, 1973·The Biochemical Journal·S O TottmarK H Kiessling
Feb 1, 1972·The Journal of Cell Biology·O GreengardW E Knox
Dec 1, 1974·Analytical Biochemistry·P SherlineD M Kipnis
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 1, 1972·Analytical Biochemistry·R F MartinL R Finch
Mar 1, 1972·The Biochemical Journal·K N JeejeebhoyU Sodtke
Dec 22, 1970·Biochimica Et Biophysica Acta·E Bjorklid, L Helgeland
Sep 1, 1971·The Journal of Clinical Investigation·M A RothschildS S Schreiber
Mar 1, 1961·The Biochemical Journal·A H GORDON, J H HUMPHREY

❮ Previous
Next ❯

Citations

Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L KennerH Denk
Mar 17, 1978·European Journal of Clinical Pharmacology·H I PirttiahoR O Pelkonen
Mar 15, 1983·Klinische Wochenschrift·M Nishimura, R Teschke
Feb 7, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·S R Cairns, T J Peters
Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·O P SharmaR K Dawra
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·Y Israel, H Orrego
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·Y MatsudaS Takase
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·M Varga, L Buris
Jan 1, 1990·Pharmacology & Therapeutics·C S Lieber
Jul 1, 1995·Journal of Hepatology·K NakajimaO Masamune
Dec 14, 1995·Biochimica Et Biophysica Acta·K K KharbandaT M Donohue
Feb 1, 1981·Toxicology Letters·O P SharmaS S Negi
Jan 1, 1989·Free Radical Biology & Medicine·N J Schisler, S M Singh
Sep 1, 1993·Baillière's Clinical Gastroenterology·D J Harrison, A D Burt
Jan 16, 2002·Prostaglandins & Other Lipid Mediators·Ichiro WakabayashiMunetaka Negoro
Apr 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R G CameronC Tiribelli
May 11, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Brittany A LawWayne E Carver
Jun 21, 2002·Asia Pacific Journal of Clinical Nutrition·Rajagopal Senthil KumarNamasivayam Nalini
Mar 17, 1977·The New England Journal of Medicine·H L Bleich, E S Boro
Apr 20, 1978·The New England Journal of Medicine·C S Lieber
Aug 3, 1978·The New England Journal of Medicine·D F Busch
Dec 1, 1991·Journal of the American College of Nutrition·C S Lieber
Jan 1, 1991·Drug and Alcohol Review·C S Lieber
Jan 1, 1992·Journal of Gastroenterology and Hepatology·H Orrego, F J Carmichael
Sep 1, 1992·Journal of Gastroenterology and Hepatology·K FurutaS Furuta
Dec 1, 1990·Alcoholism, Clinical and Experimental Research·L E Rikans, L P Gonzalez
Aug 1, 1991·Alcoholism, Clinical and Experimental Research·C S Lieber
Aug 1, 1992·Alcoholism, Clinical and Experimental Research·B J PotterO Beloqui
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·R Wondergem, J Davis
Jun 1, 1994·Alcoholism, Clinical and Experimental Research·T M DonohueR K Zetterman
Jun 20, 2001·Alcoholism, Clinical and Experimental Research·T M DonohueS S Barve
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·P de la M HallJ C Bode
Feb 1, 2002·Alcoholism, Clinical and Experimental Research·Patricia E MolinaManuela Neuman
Jul 1, 1979·Journal of Clinical Pathology·J K KellyA Milford-Ward
Aug 15, 2000·Annual Review of Nutrition·C S Lieber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K K KharbandaT M Donohue
Alcoholism, Clinical and Experimental Research
T M DonohueR K Zetterman
© 2022 Meta ULC. All rights reserved