PMID: 11909845Mar 23, 2002Paper

Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis

The Journal of Antimicrobial Chemotherapy
Johannes K-M KnoblochDietrich Mack

Abstract

The pathogenesis of Staphylococcus epidermidis is correlated with biofilm formation. We investigated the effect of three common alcoholic skin disinfectants, ethanol, n-propanol and isopropanol, on the biofilm formation of 37 clinical, icaADBC-positive S. epidermidis isolates. In alcohol-supplemented media 18 strains displayed increased biofilm expression. Sixteen of 19 strains were generally incapable of biofilm formation. In three representative isolates, the increase in biofilm formation was paralleled by increased polysaccharide intercellular adhesin synthesis. Regarding the widespread use of alcoholic skin disinfectants, it is possible that the alcohol-inducible biofilm phenotype of S. epidermidis could add to the development of foreign body-related infections.

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Citations

Sep 7, 2006·Analytical and Bioanalytical Chemistry·Dietrich MackJohannes K-M Knobloch
Apr 7, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R BradfordM Deighton
Mar 15, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Fernanda GomesRosário Oliveira
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