Alcoholic Liver Disease and Hepatitis C Chronic Infection

Reviews on Recent Clinical Trials
Alessandro FedericoCarmela Loguercio

Abstract

Alcoholic and virus C hepatitis currently represent the main causes of chronic liver disease worldwide. Every year many people die and are subjected to complex hospitalization and medical assistance due to these pathologies. Alcoholic liver disease and hepatitis C virus chronic infection are often present in the same patient. These two pathologies sinergically act in determining the onset and progression of liver damage that, from the chronic hepatitis staging, may rapidly progress to fibrosis, cirrhosis and hepatocellular carcinoma. In this review we analysed physiopathological aspects and biomolecular interactions that relate ethanol and hepatitis C virus in determining liver damage; moreover we took into account the effect on the natural history of liver disease deriving from the co-presence of these pathologies. Therefore we paid particular attention to the ability of ethanol and hepatitis C virus to in inducing oxidative stress or lipid accumulation, and analyzed the basic mechanisms of fibrogenesis that both diseases have got, amplified by their co-presence in the same patient. Finally we paid attention to the oncogenetic mechanisms inducing hepatocellular carcinoma and variability of response to antiviral therapy that de...Continue Reading

Citations

Jan 26, 2018·Open Forum Infectious Diseases·Janne Fuglsang HansenCourt Pedersen
Apr 4, 2017·British Journal of Biomedical Science·Abdelfattah M AttallahKhaled Farid
Jan 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandro FedericoCarmelina Loguercio

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