Alcoholic liver disease: Clinical and translational research

Experimental and Molecular Pathology
Manuela G NeumanSamuel W French

Abstract

The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a legally commercialized and taxable product. Drinking alcohol, particularly from a young age, is a major health problem. Alcoholism is known to contribute to morbidity and mortality. A systematic literature search was performed in order to obtain updated data (2008-2015). The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD. Alcohol-mediated hepatocarcinogenesis is also discussed in the presence or absence of co-morbidities such as viral hepatitis C as well as therapeutic the role of innate immunity in ALD-HCV. Moreover, emphasis was placed on alcohol and drug interactions, as well as liver transplantation for end-stage ALD. Finally, the time came to eradicate alcohol-induced liver and intestinal damage by using betaine.

References

Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·T YukiR G Thurman
Jun 1, 1995·The New England Journal of Medicine·M J TongR L Co
Dec 11, 1997·The New England Journal of Medicine·M J ThunR Doll
Dec 3, 1998·Alcoholism, Clinical and Experimental Research·R K Rao
Jan 22, 2000·Annals of Internal Medicine·L B SeeffE L Kaplan
Jul 25, 2000·JAMA : the Journal of the American Medical Association·D L ThomasD Vlahov
Jan 15, 2002·The Journal of Biological Chemistry·Michael P MalakhovDong-Er Zhang
Mar 12, 2002·European Journal of Clinical Investigation·Gemino FiorelliM D Cappellini
Feb 26, 2003·Genes & Development·Oxana A MalakhovaDong-Er Zhang
Jun 11, 2003·Archives of Internal Medicine·S Goya WannametheeEric B Rimm
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Christiane Bode, J Christian Bode
Dec 4, 2003·The Journal of Laboratory and Clinical Medicine·Ali Keshavarzian, Jeremy Fields
May 11, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·R K RaoP Sheth
May 29, 2004·Alcoholism, Clinical and Experimental Research·P ShethR K Rao
Aug 28, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·A SethR K Rao
Nov 30, 2004·Journal of Medicinal Chemistry·Anu J TervoAntti Poso
Jan 19, 2005·Journal of Viral Hepatitis·A A ButtJ Ahmad
Oct 4, 2005·Alimentary Pharmacology & Therapeutics·A ChangF K Friedenberg
Oct 21, 2005·Journal of Hepatology·Manfred WieseUNKNOWN East German Hepatitis C Study Group
Oct 29, 2005·Biochemical Pharmacology·Kusum K KharbandaDean J Tuma
Jun 8, 2006·Annual Review of Biochemistry·Anthony A SauveJef D Boeke
Jun 14, 2006·Experimental and Molecular Pathology·Fawzia Bardag-GorceSamuel W French
Aug 10, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Sep 7, 2007·Biotechnology Journal·Walter StünkelJeanette Wood
Oct 12, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Cynthia KoKris V Kowdley
Feb 2, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Min YouGene C Ness
May 6, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winston DunnJeffrey B Schwimmer
Jul 10, 2008·Journal of the National Cancer Institute·Leo R ZacharskiPhilip W Lavori
Dec 25, 2008·PloS One·Tsutomu SasakiHeidi Scrable

❮ Previous
Next ❯

Citations

Mar 10, 2017·Gut and Liver·Felix StickelRamon Bataller
Sep 29, 2017·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pierre Beaulieu
Aug 27, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natalie J Torok
Feb 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·He PeiyuanMustapha Umar Imam
Feb 26, 2019·Therapeutic Drug Monitoring·Manuela G Neuman
Mar 19, 2019·Therapeutic Drug Monitoring·Manuela G Neuman
May 30, 2021·Experimental Cell Research·Jennifer H BenbowLaura W Schrum
Jul 27, 2021·Frontiers in Physiology·Manuela G NeumanSebastian Mueller
Oct 3, 2020·Journal of Ethnopharmacology·Houkang CaoLing Jin
May 13, 2019·Life Sciences·Xufei ZhangUNKNOWN Lab for Trauma and Surgical Infections

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Manuela G NeumanH K Seitz
Experimental and Molecular Pathology
Manuela G NeumanSteve Malnick
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Yangyang ChenKeqin Xie
Midwife, Health Visitor & Community Nurse
M M Glatt
© 2021 Meta ULC. All rights reserved