Alcoholic Liver Disease: Role of Cytokines

Biomolecules
Manuela G NeumanStephen Malnick

Abstract

The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical and translational research. It focuses on the role of the immune system and the signaling pathways of cytokines in the pathogenesis of ALD. An additional factor that contributes to the pathogenesis of ALD is lipopolysaccharide (LPS), which plays a central role in the induction of steatosis, inflammation, and fibrosis in the liver. LPS derived from the intestinal microbiota enters the portal circulation, and is recognized by macrophages (Kupffer cells) and hepatocytes. In individuals with ALD, excessive levels of LPS in the liver affect immune, parenchymal, and non-immune cells, which in turn release various inflammatory cytokines and recruit neutrophils and other inflammatory cells. In this review, we elucidate the mechanisms by which alcohol contributes to the activation of Kupffer cells and the inflammatory cascade. The role of the stellate cells in fibrogenesis is also discussed.

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Citations

Apr 20, 2016·Biomolecules·Natalia A Osna, Kusum K Kharbanda
Mar 21, 2017·The Journal of Nutritional Biochemistry·Paul G ThomesLaura W Schrum
Jan 13, 2017·Experimental and Molecular Pathology·Manuela G NeumanMihai Opris
Feb 26, 2019·Therapeutic Drug Monitoring·Manuela G Neuman
May 4, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei LiQigui Yu
Jun 23, 2018·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Cyriac Abby PhilipsPhilip Augustine
May 23, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zhaohuan LouHongying Pan
Dec 26, 2018·Critical Reviews in Food Science and Nutrition·Meng WangJian-Bo Wan
Mar 19, 2019·Therapeutic Drug Monitoring·Manuela G Neuman
Mar 13, 2021·Life Sciences·Arunraj Namachivayam, Abilash Valsala Gopalakrishnan
Apr 6, 2021·Frontiers in Pharmacology·Xiao-Han TangSteven E Trasino
Dec 1, 2020·Pharmacology & Therapeutics·Bingjian WenZhengquan Su

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Methods Mentioned

BETA
biopsy
biopsies

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