PMID: 9553600Apr 29, 1998Paper

Alcoholic liver disease. Treatment strategies for the potentially reversible stages

Postgraduate Medicine
D B Hill, M Kugelmas

Abstract

Even modest alcohol ingestion can increase the risk of steatosis, and long-term, excessive consumption can lead to alcoholic hepatitis and eventually cirrhosis. Most patients with clinically significant alcoholic liver disease have histologic findings typical of all three conditions. The only clearly beneficial treatment is abstinence from alcohol. Abstinence in combination with proper nutrition and general supportive care is state of the art. Steatosis is reversible upon withdrawal of alcohol, but alcoholic hepatitis can persist even with abstinence and may progress to cirrhosis. Corticosteroid therapy may reduce short-term mortality rates in patients with moderate or severe alcoholic hepatitis who have hepatic encephalopathy but no evidence of infection or gastrointestinal bleeding. Treatment with colchicine may decrease the risk of cirrhosis; however, once cirrhosis has developed, the liver damage is irreversible. The prognosis is improved with abstinence, but complications (e.g., ascites, gastrointestinal bleeding) often occur. Liver transplantation may be considered in patients with severe complications.

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Citations

Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Priscilla IvesterCarol Cunningham
Apr 11, 2008·Journal of Gastroenterology and Hepatology·Samuele De Minicis, David A Brenner
Jan 13, 2011·Alcoholism, Clinical and Experimental Research·Razia S Aziz-SeibleCarol A Casey
Mar 2, 2002·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·F DobbelsY Vanrenterghem
Jan 13, 2012·Experimental Biology and Medicine·Juliane I Beier, Gavin E Arteel

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