PMID: 6974036Aug 1, 1981Paper

Alcohol's effect on body temperature: hypothermia, hyperthermia or poikilothermia?

Brain Research Bulletin
R D Myers

Abstract

A series of five experiments was undertaken in order to characterize the pharmacological effects of alcohol on the body temperature of the unrestrained rat. After a thermistor probe was fixed within the colon of each animal and its body temperature had stabilized, physiological saline. 2.0 g/kg or 4.0 g/kg of ethyl alcohol was given by intragastric gavage. A constant concentration of 20% was utilized with doses determined volumetrically according to the individual weight of the animal. The following observations were made: (1) At a laboratory room temperature of 22 degrees C, alcohol produced a dose-dependent decline in colonic temperature. This fall was enhanced when the rat was placed in a chamber with an ambient temperature of 8 degrees C, but reversed into a hyperthermic response when the ambient temperature of the rat was elevated to 36 degrees C. (2) If the rat was exposed for one hour to either a warm (36 degrees C) or cold (8 degrees C) ambient temperature beginning at the time of the intragastric gavage with alcohol, the body temperature of the animal correspondingly decreased or increased, respectively. The magnitude of the shift in the animal's colonic temperature depended solely on the dose of alcohol given, i.e., t...Continue Reading

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Citations

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