Aldehyde dehydrogenase 1 as a predictor of the neoadjuvant chemotherapy response in breast cancer: A meta-analysis

Medicine
Jie LiYong Hong Liu

Abstract

Many reports suggest that aldehyde dehydrogenase 1 (ALDH1) expression is associated with poorer neoadjuvant chemotherapy (NAC) response in patients with breast cancer; however, the prognostic value of this enzyme in cancer has yet to be confirmed. Therefore, we conducted a meta-analysis of related studies to investigate the relationship between ALDH1 expression and the NAC response in breast cancer patients. PubMed, Web of Science, ScienceDirect, Cochrane Library, and EMBASE were searched for potentially eligible literature. The study characteristics and relevant data were extracted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of ALDH1 in the NAC response in patients with breast cancer. The robustness of our results was confirmed by sensitivity and publication bias analyses. Pooled meta-analysis of 10 eligible studies including 1081 patients indicated an association between high ALDH1 expression and poor NAC responses (pooled OR = 0.44, 95% CI: 0.25-0.77, P = .004) with low significant heterogeneity (I = 55.1%, P = .018). During subgroup analyses, we found that the recipient sample size presents a potential source of heterogeneity. Begg funnel plot and Egger test showed no p...Continue Reading

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Citations

Oct 30, 2019·Molecular and Cellular Biology·Maria A VoronkovaYon Rojanasakul
May 30, 2020·International Journal of Oncology·Daniel L PouliquenCatherine Guette

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Software Mentioned

QUADAS
MP
STATA
PROSPERO
PRISMA

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