Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Eiichiro SuzukiOsamu Yokosuka

Abstract

It has been reported that aldehyde dehydrogenase 1 A1 (ALDH1) could be not only a normal stem cell marker but also a cancer stem cell marker. ALDH1 expression could be a predictor of poor prognosis in a wide range of cancers. However, the role of ALDH1 in hepatocellular carcinoma (HCC) remains unclear. We conducted loss-of-function assays for ALDH1 by using short-hairpin RNA in HCC cells and evaluated the correlation between ALDH1 expression and clinicopathological features based on immunohistochemical assessment of 49 primary HCC tissues. Neither cell proliferation nor the anchorage-independent sphere formation ability of HCC cells were altered after ALDH1 knockdown. Flow cytometric analyses revealed that ALDH1 knockdown showed no remarkable change in the proportion of epithelial cell adhesion molecule (EpCAM)(+) tumor-initiating cells. Although non-tumor tissues in primary HCC samples diffusely and homogenously expressed ALDH1 at low levels, tumor tissues contained cells with high levels of ALDH1 expression at varying frequencies. Primary HCC samples were categorized as ALDH1-high or ALDH1-low based on the percentage of ALDH1-overexpressing cells. ALDH1-high HCC was characterized by low serum levels of α-fetoprotein (P < 0.01...Continue Reading

References

Nov 2, 2001·Nature·T ReyaI L Weissman
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·Norman E Sládek
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tetsuhiro ChibaHideki Taniguchi
Jul 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·John P ChuteDonald P McDonnell
Aug 1, 2007·The Journal of Experimental Medicine·Eva SchmelzerLola M Reid
Jul 10, 2008·Expert Opinion on Drug Metabolism & Toxicology·Satori A MarchittiVasilis Vasiliou
Jul 23, 2008·Molecular Cancer Research : MCR·Stephanie MaXin-Yuan Guan
Feb 3, 2009·The Lancet Oncology·Nathalie Druesne-PecolloPaule Latino-Martel
Mar 12, 2009·Molecular Cancer Research : MCR·Feng JiangRuth L Katz
Mar 31, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bin ChangJinsong Liu
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomonori TaneiShinzaburo Noguchi
Nov 17, 2009·Breast Cancer Research and Treatment·Erika ResetkovaSunil Badve
Jul 1, 2011·International Journal of Cancer. Journal International Du Cancer·Tetsuhiro ChibaOsamu Yokosuka
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Laurent DolléLeo A van Grunsven

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Citations

Feb 12, 2014·Journal of Cancer Research and Therapeutics·Shaoqiang Sun, Xue Shan Qiu
Apr 27, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshimasa SaitoHidetsugu Saito
Jan 21, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laura A TaylorXiaowei Xu
Jan 20, 2016·Oncotarget·Hiroyuki TomitaAkira Hara

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