PMID: 3755605May 1, 1986Paper

Aldehyde dehydrogenases, aldehyde oxidase and xanthine oxidase from baboon tissues: phenotypic variability and subcellular distribution in liver and brain

Alcohol
R S Holmes, J L VandeBerg

Abstract

Isoelectric focusing (IEF) and cellulose acetate electrophoresis were used to examine the multiplicity and distribution of aldehyde dehydrogenases (ALDHs), aldehyde oxidase (AOX) and xanthine oxidase (XOX) from tissues of olive and yellow baboons. Five ALDHs were resolved and distinguished on the basis of their differential tissue and subcellular distribution or substrate specificity. Some ALDHs exhibited multiple activity zones. Baboon liver ALDHs were differentially distributed in cytosol (ALDHs II, III and V) and large granular (mitochondrial) fractions (ALDHs I and IV). The major liver ALDHs (I and II) were also broadly distributed in other tissues, as was the major stomach enzyme (ALDH-III). Three brain ALDHs were resolved, which were also differentially distributed between large granular (mitochondrial) (ALDHs I and IV) and cytosolic (ALDH-III) fractions. Electrophoretic variability between individuals was observed for the major liver mitochondrial isozyme (ALDH-I), the major stomach isozyme (ALDH-III) and the minor liver isozymes (ALDHs IV and V). Single forms of AOX and XOX were found in baboon tissue extracts, with the highest activities in liver (AOX) and intestine extracts (XOX). Both oxidases were predominantly loca...Continue Reading

References

Jul 1, 1977·European Journal of Biochemistry·A K MacGibbonP D Buckley
Apr 1, 1978·Alcoholism, Clinical and Experimental Research·R D Myers
Oct 2, 1979·Human Genetics·H W GoeddeD P Agarwal
Jan 1, 1977·Nutrition and Metabolism·H Sarles
Aug 1, 1976·Archives of Biochemistry and Biophysics·J H Eckfeldt, T Yonetani
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L C HsuA Yoshida
May 1, 1985·Alcoholism, Clinical and Experimental Research·J A DuleyR S Holmes
Jan 1, 1985·The International Journal of Biochemistry·E M Algar, R S Holmes
May 1, 1985·Alcohol·C M Forte-McRobbie, R Pietruszko
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·U K Rout, R S Holmes
Sep 15, 1974·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K H Wurzinger, R Hartenstein
Dec 1, 1966·Biochemical Pharmacology·R A Deitrich
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·Y MizoiI Ijiri
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·C S Lieber, L M DeCarli
Aug 15, 1981·Biochemical Pharmacology·M E LebsackC S Lieber
Jan 1, 1981·Human Heredity·Y S Teng
Jan 1, 1980·Pharmacology, Biochemistry, and Behavior·K O LindrosM Salaspuro
May 1, 1940·The Biochemical Journal·A H GordonV Subrahmanyan

❮ Previous
Next ❯

Citations

Jan 1, 1991·Journal of Neurochemistry·S M Zimatkin
Jun 1, 1997·Journal of Medical Primatology·J L VandeBerg, S Williams-Blangero
Dec 1, 1994·The Journal of Clinical Investigation·J S WiezorekC A Brass
Sep 1, 1986·Experimental Eye Research·R S Holmes, J L Vandeberg
Oct 1, 1988·Alcoholism, Clinical and Experimental Research·K L GuanH Weiner
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·R Lindahl
Feb 18, 2012·International Journal of Cancer. Journal International Du Cancer·Jochen SpringerWolfram Doehner
Feb 1, 1991·Hypertension·H TrachtmanS Futterweit
Mar 1, 1991·Circulation·S W WernsB R Lucchesi
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jessica LawrenceDavid Argyle
Jul 31, 2019·Alimentary Pharmacology & Therapeutics·Joany E KreijneUNKNOWN of the Dutch Initiative on Crohn, Colitis (ICC)
Jan 1, 2014·Antioxidants·Rachel ShirleyLorraine M Work
Jan 10, 2020·Journal of Diabetes Investigation·Masato FuruhashiTetsuji Miura
Jul 13, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Roderic H FabianThomas A Kent
Mar 12, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Caren S BavarescoAngela T S Wyse
Dec 25, 2003·The Journal of Physiology·Cristine E Berry, Joshua M Hare
Mar 11, 2008·Experimental Dermatology·Mohammad ShalbafKarin U Schallreuter
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·A J van DijkJ Fink-Gremmels
Nov 18, 2003·Acta Physiologica Scandinavica·J L Garvin, P A Ortiz
Nov 1, 1987·Annals of the Rheumatic Diseases·R E AllenD R Blake
Dec 30, 2009·Human Genomics·Enrico GarattiniMineko Terao
Feb 1, 1989·Gastroenterologia Japonica·S TakaseA Takada
Dec 6, 2018·Journal of Diabetes Investigation·Masato FuruhashiTetsuji Miura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.