ALDH2 promoter polymorphism has no effect on the risk for alcoholism

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Mitsuru KimuraSusumu Higuchi

Abstract

To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism. Genotyping to identify the polymorphisms in 515 alcoholic patients and 361 normal controls was performed. There were no significant differences between the genotype and allele frequencies of the -357A/G polymorphism in alcoholics and normal controls. Linkage disequilibrium was observed between the promoter and exon 12 polymorphisms. These results suggest the ALDH2 promoter polymorphism does not affect the risk for alcoholism.

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Citations

Jan 16, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Yukiko KimuraKiyofumi Saijoh
Feb 3, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Naiara G BediagaAmelia Acha-Sagredo
Sep 11, 2008·Alcoholism, Clinical and Experimental Research·Lise Lotte Nystrup HusemoenAllan Linneberg
Oct 16, 2018·Alcoholism, Clinical and Experimental Research·Howard J Edenberg, Jeanette N McClintick
Nov 8, 2019·Expert Opinion on Therapeutic Targets·Mitsuru KimuraSusumu Higuchi

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