Abstract
Aldehyde dehydrogenase 2 (ALDH2) is a new therapeutic target in the central nervous system. However, the association between ALDH2 and brain edema following ischemic stroke (IS) remains unclear. The present study was investigated to whether active ALDH2 can attenuate brain edema by using a rat model of IS, with the aim of clarifying the underlying mechanisms involved. Rats were administered the ALDH2 agonist Alda-1, vehicle or the ALDH2 inhibitor cyanamide (CYA) 15 min prior to a 1.5 h middle cerebral artery occlusion (MCAO) surgery. The effects of ALDH2 were subsequently investigated 24 h after reperfusion by evaluating neurological function, infarct sizes, brain edema volumes, 4-hydroxy-2-nonenal (4-HNE) levels, and aquaporin 4 (AQP4) protein expression. The results demonstrated that increasing ALDH2 activity significantly improved neurological deficits, reduced infarct sizes, and attenuated brain edema after MCAO. Alda-1 administration led to decreased 4-HNE levels and inhibited AQP4 protein expression in the peri-infarct section of the brain. Whereas, CYA administration increased 4-HNE levels, AQP4 expression, and simultaneously aggravated brain edema following MCAO. In conclusion, increasing ALDH2 activity can improve brai...Continue Reading
References
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 1, 1987·Acta Medica Scandinavica·M ViitanenK Asplund
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·J H GarciaX J Hu
Feb 2, 2000·Nature Medicine·G T ManleyA S Verkman
May 1, 2001·IUBMB Life·G Poli, R J Schaur
Feb 14, 2002·Free Radical Biology & Medicine·Nicola TraversoUmberto M Marinari
Jul 31, 2003·The Journal of Biological Chemistry·Yusong YangYogesh C Awasthi
Aug 29, 2003·The Journal of Biological Chemistry·Hajime ArimaKiyofumi Asai
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yuri Ikeda-MatsuoYasuharu Sasaki
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Sep 13, 2008·Science·Che-Hong ChenDaria Mochly-Rosen
Dec 20, 2008·Handbook of Experimental Pharmacology·Zsolt ZadorGeoffrey T Manley
Jan 24, 2009·Human Genomics·Giia-Sheun Peng, Shih-Jiun Yin
Jan 30, 2010·Behavioural Brain Research·Jianping WangYujin Hao
Apr 16, 2010·Journal of Neurotrauma·Radhika A VaishnavEdward D Hall
Nov 9, 2010·Life Sciences·Ling-Ling QiEr-Qing Wei
May 17, 2011·Nature Genetics·Norihiro KatoJiang He
Jul 2, 2011·EMBO Reports·Zhongping LuMichael N Sack
May 22, 2013·Cell Research·Jin-Min GuoDing-Feng Su
Oct 2, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Si-Hai FuJun Peng
Oct 15, 2014·PloS One·Heng YangRen Guo
Apr 24, 2015·Frontiers in Cellular Neuroscience·Jasmine VellaMario Valentino
Jul 15, 2015·International Journal of Stroke : Official Journal of the International Stroke Society·Wei WangAi-Jun Liu
Aug 9, 2015·Brain, Behavior, and Immunity·Aneta StachowiczRyszard Korbut
Aug 16, 2016·The FEBS Journal·Javier A Belmont-DíazJosé S Rodríguez-Zavala
Citations
Jun 19, 2019·Aging·Sahebgowda Sidramagowda PatilLakshmi Galam
Feb 6, 2021·Brain Research·Mushfiquddin KhanInderjit Singh
Feb 23, 2021·Frontiers in Aging Neuroscience·Yi YaoJianzhao Luo
Aug 8, 2021·Biomedical Engineering Online·Lingxiao PanMinzhe Zheng
Apr 4, 2019·Journal of Medical Virology·Lei ZhuBo-Xiang Qi
Feb 27, 2020·Cardiology·Yi LinWenjun Ding