Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy

Chemistry : a European Journal
Subhash C SinhaCarlos F Barbas

Abstract

Prodrugs of potent aldehyde analogues of the anticancer drug doxorubicin (Dox) were synthesized. These prodrugs were efficiently activated by antibody 93F3 and no drug formation was observed in the absence of 93F3 in either phosphate buffered saline or cell culture media. In the presence of antibody 93F3, these prodrugs were activated and decreased the proliferation of human cancer cells in in vitro proliferation assays.

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Citations

Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sunny AbrahamSubhash C Sinha
Nov 1, 2005·Expert Review of Clinical Immunology·Kerry A ChesterAstrid Mayer
Sep 17, 2010·Chembiochem : a European Journal of Chemical Biology·Julia GavrilyukCarlos F Barbas
Oct 18, 2008·The Journal of Organic Chemistry·M-Lluïsa BennasarDavinia García-Díaz

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