PMID: 6403351Mar 15, 1983Paper

Aldose and aldehyde reductase exhibit isocorticosteroid reductase activity

European Journal of Biochemistry
B Wermuth, C Monder

Abstract

In this paper we describe the reduction of corticosteroid metabolites containing the 17 beta-aldol side chain (isocorticosteroids) by aldose and aldehyde reductase from human tissues. Aldose reductase catalyzed the reduction of the aldehydes derived from cortisol and corticosterone at about the same rate, whereas aldehyde reductase preferentially acted on the aldehydes derived from 17-deoxycorticosteroids. At comparable rates of reduction the Michaelis constants for the best steroid aldehydes were one order of magnitude lower than for the hitherto best substrates. We propose that aldose and aldehyde reductase participate in the conversion of the corticosteroid ketol side chain to the glycol side chain via an aldol intermediate by the 'long loop' pathway proposed by Monder and Bradlow [(1977) J. Steroid Biochem. 8, 897-908].

References

Aug 1, 1977·Journal of Steroid Biochemistry·C Monder, H L Bradlow
Jul 9, 1976·The Journal of Organic Chemistry·S W Oh, C Monder
Jan 1, 1975·The Journal of Clinical Endocrinology and Metabolism·C MonderL Hellman
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·H L BradlowL Hellman
Jan 1, 1982·Methods in Enzymology·J P von Wartburg, B Wermuth
Jan 1, 1982·Methods in Enzymology·B Wermuth, J P von Wartburg
Jan 1, 1960·Biochimica Et Biophysica Acta·H G HERS

❮ Previous
Next ❯

Citations

Jan 1, 1991·Steroids·C Monder, A Marandici
Apr 18, 2001·Chemico-biological Interactions·A MartinezA Lefrançois Martinez
Sep 1, 1996·Steroids·T M PenningM Lewis
Dec 12, 2003·Genomics·Oleg A BarskiKenneth H Gabbay
Apr 4, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Roland ChungOssama El-Kabbani
Sep 3, 2005·Reproductive Biology and Endocrinology : RB&E·Junichi FujiiFutoshi Okada
Sep 11, 2013·PloS One·Antonella Del-CorsoUmberto Mura
Apr 17, 2012·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Krithika SundaramOssama El-Kabbani
Mar 8, 2012·Toxicology Mechanisms and Methods·Citlalli Osorio-YáñezArnulfo Albores
Oct 25, 2008·Drug Metabolism Reviews·Oleg A BarskiAruni Bhatnagar
Oct 11, 2008·Chemico-biological Interactions·Satoshi EndoOssama El-Kabbani
Jul 4, 2012·Molecular Reproduction and Development·Jessica LaroseJean-François Bilodeau
Sep 19, 2006·European Journal of Pharmacology·Vinicius F CarvalhoPatrícia M R e Silva
Apr 18, 2001·Chemico-biological Interactions·K V RamanaS K Srivastava
Sep 16, 1999·Genomics·O A BarskiK M Bohren
Feb 6, 1990·Biochemistry·A Marandici, C Monder
Apr 1, 1988·Medicinal Research Reviews·E R LarsonR Sarges
Apr 15, 2000·The Journal of Biological Chemistry·B L DixitS K Srivastava
Oct 4, 2000·Biochemistry·K V RamanaA Bhatnagar
Jul 24, 1998·Archives of Biochemistry and Biophysics·K J Rees-MiltonT G Flynn
Mar 2, 1999·Biochemical and Biophysical Research Communications·H LiC Yabe-Nishimura
Nov 26, 2018·Theriogenology·H B A BastosR C Mattos
Jun 3, 2021·Metabolites·Junichi FujiiMotoko Takahashi
Nov 15, 1989·Biochemical and Biophysical Research Communications·P SteinerstauchH C Curtius
Jan 31, 1998·Biochemistry·A ChandraS K Srivastava
May 26, 2009·Archives of Biochemistry and Biophysics·Satoshi EndoAkira Hara
Dec 29, 2009·European Journal of Medicinal Chemistry·Vincenzo CarboneOssama El-Kabbani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.