Abstract
We report the independent risk association of type 2 diabetic nephropathy with the z-2 allele of the 5'-(CA)(n) microsatellite and C-106T promoter polymorphisms of the aldose reductase gene (ALR2) using a case-control design. In this expanded cohort, we examined their predictive roles on new onset of cardiorenal complications using a prospective design. In this 8-year prospective cohort of 1,074 type 2 diabetic patients (59% male, median age 61 years; disease duration 7 years) with an observation period of 8,592 person-years, none had clinical evidence of coronary heart disease (CHD) or chronic kidney disease at recruitment. The renal end point was defined as new onset of estimated glomerular filtration rate <60 ml/min per 1.72 m(2) or hospitalizations with dialysis or death due to renal disease, and CHD was defined as hospitalizations with myocardial infarction, ischemic heart disease, or related deaths. After controlling for baseline risk factors and use of medications, we found that the ALR2 z-2 allele of (CA)(n) microsatellite carriers had increased risk of renal (hazard ratio 1.53 [95% CI 1.14-2.05], P = 0.005) or combined cardiorenal (1.31 [1.01-1.72], P = 0.047) end points. Carriers of the ALR2 C-106T polymorphism also h...Continue Reading
References
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jul 9, 1998·The New England Journal of Medicine·P FiorettoM Mauer
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·V O ShahP G Zager
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·J Kapor-DrezgicC Whiteside
Aug 28, 2001·Journal of Diabetes and Its Complications·K IsoT Inokuchi
Oct 6, 2001·Diabetologia·N J MorrishH Keen
Dec 11, 2002·Kidney International·Amanda I AdlerUNKNOWN UKPDS GROUP
Mar 20, 2003·Current Diabetes Reports·G ImperatoreR L Hanson
Jul 29, 2003·Diabetes Care·Ying WangJuliana C N Chan
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Mar 30, 2004·Diabetes Care·Juliana C N ChanUNKNOWN Asian RENAAL Study Investigators
Dec 8, 2004·Endocrine Reviews·Bieke F SchrijversAllan Flyvbjerg
Aug 30, 2005·The Journal of Clinical Investigation·Reeba K VikramadithyanIra J Goldberg
Aug 29, 2006·Diabetes Care·Wing Yee SoPeter C Y Tong
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Oct 27, 2006·Diabetes Care·Peter C Y TongJuliana C N Chan
Mar 22, 2007·JAMA : the Journal of the American Medical Association·Ph Gabriel StegUNKNOWN REACH Registry Investigators
Apr 14, 2007·Diabetologia·X L YangJ C N Chan
Feb 8, 2008·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Mar 1, 2008·The American Journal of Cardiology·Xilin YangPeter C Y Tong
Mar 12, 2008·Archives of Internal Medicine·UNKNOWN Hong Kong Diabetes RegistryJuliana C N Chan
Apr 26, 2008·Endocrine Reviews·Stephanie T PageWilliam J Bremner
Citations
Jan 27, 2011·Diabetologia·H LiuJ Y Yang
Sep 14, 2010·Current Diabetes Reports·Alessandro Doria
May 15, 2010·Circulation Research·Ravichandran Ramasamy, Ira J Goldberg
Aug 30, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sami Alkayyali, Valeriya Lyssenko
Dec 24, 2013·Journal of Diabetes and Its Complications·Ying WangJuliana C N Chan
May 1, 2009·Diabetes/metabolism Research and Reviews
May 1, 2012·American Journal of Medical Genetics. Part a·Sheri MitchellPinar Bayrak-Toydemir
Apr 18, 2015·European Journal of Medical Research·Wenpeng CuiWenhua Zhou
Jun 16, 2015·Frontiers in Endocrinology·Ini-Isabée WitzelHabiba Alsafar
Jun 28, 2016·Gene·Yaqin WangDong-Sheng Ouyang
May 18, 2016·Journal of Diabetes Investigation·Yasuo Ido
Oct 13, 2016·Indian Journal of Endocrinology and Metabolism·Azhar Mohamed NomairDalia Aly Maharem
Apr 5, 2014·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yu DengNing-pu Liu
Jun 27, 2017·Diabetes Research and Clinical Practice·Yan-Yan LiXin-Zheng Lu
May 29, 2013·Nature Reviews. Endocrinology·Alice P S KongJuliana C N Chan
Feb 8, 2011·Genetic Testing and Molecular Biomarkers·Jing-cheng WuYong-de Peng
Jun 13, 2018·Diabetes·Chujun YuanEdward A Fisher
Jun 10, 2011·Current Cardiovascular Risk Reports·Juliana C N ChanXilin Yang
Mar 30, 2021·Frontiers in Endocrinology·Sravya JannapureddyRavichandran Ramasamy
Mar 20, 2010·Current Opinion in Pediatrics