Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells.

Free Radical Biology & Medicine
Viktor R DrelIrina G Obrosova

Abstract

Both increased aldose reductase (AR) activity and oxidative/nitrosative stress have been implicated in the pathogenesis of diabetic nephropathy, but the relation between the two factors remains a subject of debate. This study evaluated the effects of AR inhibition on nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in diabetic rat kidney and high-glucose-exposed human mesangial cells. In animal experiments, control (C) and streptozotocin-diabetic (D) rats were treated with/without the AR inhibitor fidarestat (F, 16 mg kg(-1) day(-1)) for 6 weeks starting from induction of diabetes. Glucose, sorbitol, and fructose concentrations were significantly increased in the renal cortex of D vs C (p < 0.01 for all three comparisons), and sorbitol pathway intermediate, but not glucose, accumulation, was completely prevented in D + F. F at least partially prevented diabetes-induced increase in kidney weight as well as nitrotyrosine (NT, a marker of peroxynitrite-induced injury and nitrosative stress), and poly(ADP-ribose) (a marker of PARP activation) accumulation, assessed by both immunohistochemistry and Western blot analysis, in glomerular and tubular compartments of the renal cortex. In vitro studies revealed the pre...Continue Reading

References

Apr 9, 1999·The Journal of Clinical Investigation·H L RittnerC M Weyand
Feb 10, 2000·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research GroupDavid M Nathan
May 3, 2000·Kidney International·R C ThuraisinghamM M Yaqoob
Sep 21, 2000·Kidney International. Supplement·E D Schleicher, C Weigert
Jan 11, 2000·Circulation Research·A FrustaciP Anversa
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·Mona F MelhemFrederick R Derubertis
Jan 5, 2001·Expert Opinion on Investigational Drugs·P J Oates, B L Mylari
Feb 24, 2001·Diabetologia·J M ForbesM E Cooper
Apr 25, 2001·Kidney International·C G Schnackenberg, C S Wilcox
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Naohito IshiiPamela K Carmines
Sep 5, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y GorinH E Abboud
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HanedaR Kikkawa
Nov 16, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irina G ObrosovaMartin J Stevens
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Mona F MelhemFrederick R DeRubertis
Jan 12, 2002·Kidney International·Maristela Lika OnozatoChristopher S Wilcox
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Sandeep GuptaJohn F Keaney
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hyo Chol HaSolomon H Snyder
Aug 30, 2002·International Review of Neurobiology·Paul J Thornalley
Jan 11, 2003·Free Radical Biology & Medicine·Irina G ObrosovaJaffar Nourooz-Zadeh
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ryuichi KikkawaMasakazu Haneda
Mar 20, 2003·Current Diabetes Reports·H Ha, H B Lee
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Azza B El-RemessyRuth B Caldwell
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander G MinchenkoIrina G Obrosova
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Toyoshi InoguchiHajime Nawata
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Hi Bahl LeeHunjoo Ha
Jul 29, 2003·Diabetes·Roya Babaei-JadidiPaul J Thornalley

❮ Previous
Next ❯

Citations

May 11, 2011·Current Diabetes Reports·Robert C Stanton
Sep 14, 2011·Nature Reviews. Neurology·Andrea M VincentEva L Feldman
Aug 30, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·U JuliusI G Obrosova
Apr 22, 2010·Nucleosides, Nucleotides & Nucleic Acids·Shereen A El TarhounyNashwa M Al Azizi
Jan 24, 2011·Journal of Diabetes Investigation·Soroku YagihashiKazuhiro Sugimoto
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Feb 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Oded N SpindelBradford C Berk
Jun 2, 2010·International Journal of Molecular Medicine·Irina G ObrosovaCarl-David Agardh
Oct 30, 2012·Journal of the Neurological Sciences·Ivana StojanovicKristina Zabar
Feb 10, 2007·Kidney International·S M HarwoodM M Yaqoob
Feb 11, 2012·Mutation Research·Artur Cieślar-PobudaJoanna Rzeszowska-Wolny
Aug 13, 2008·Journal of Ethnopharmacology·Yan-Ning LiJin-Sheng Qi
Jun 7, 2008·The American Journal of Pathology·Pal Pacher, Csaba Szabo
May 13, 2008·Archives of Biochemistry and Biophysics·Weihua LiuShu-Feng Zhou
Jul 24, 2007·European Journal of Pharmacology·Viktor R DrelIrina G Obrosova
May 4, 2007·Experimental Neurology·Igor VareniukIrina G Obrosova
Jan 28, 2009·Pharmacotherapy·Tayyeba K Ali, Azza B El-Remessy
Mar 1, 2009·Proteomics. Clinical Applications·Raymond TytherDavid Sheehan
Feb 10, 2010·Journal of Neuroscience Research·Chung-Man YeungSookja K Chung
Apr 2, 2014·Diabetes/metabolism Research and Reviews·Roman StavniichukMark A Yorek
Aug 30, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L NeshatianG Farrugia
Apr 11, 2012·Free Radical Research·Prasenjit Manna, Parames C Sil
Dec 7, 2013·Journal of Receptor and Signal Transduction Research·Tian-Biao Zhou, Zong-Pei Jiang
Jan 7, 2015·Pharmacological Reports : PR·Marwa M Safar, Rania M Abdelsalam
Sep 26, 2013·Diabetes Care·Abd A TahraniMartin J Stevens
May 12, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarManjeet Singh
Feb 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Marlene T Mathews, Bradford C Berk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.