Aldose reductase inhibitors from Viola hondoensis W. Becker et H Boss

The American Journal of Chinese Medicine
Ill-Min ChungHyung-In Moon

Abstract

The isolation and characterization of rat lens aldose reductase inhibitors from the Viola hondoensis W. Becker et H Boss were conducted. The extracts and organic fractions from V. hondoensis were tested. The MeOH extract and EtOAc fraction were found to exhibit potent rat lens aldose reductase inhibition in vitro, their IC(50) being 1.2 and 0.6 microg/ml, respectively. One major isoflavonoid glycoside was isolated from the ethyl acetate soluble fraction of V. hondoensis. Kakkalide was found to be the potential rat lens aldose reductase inhibitor (IC(50) = 0.34 microg/ml), and may be useful for the prevention and/or treatment of diabetic complications.

References

Sep 1, 1990·Biochemical Pharmacology·S Sato, P F Kador
Jan 1, 1990·Pharmacotherapy·W R Kirchain, M S Rendell
Jan 1, 1981·Breast Cancer Research and Treatment·D M MorrisD C Coker
Jun 5, 2002·Chemical & Pharmaceutical Bulletin·Hisashi MatsudaMasayuki Yoshikawa
Nov 14, 2002·Journal of Agricultural and Food Chemistry·Hoi-Seon Lee
Oct 2, 2003·Chemical & Pharmaceutical Bulletin·Chen XieMonique S J Simmonds
Jan 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H UedaM Moriyasu

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Citations

May 16, 2013·Phytotherapy Research : PTR·Ciddi VeereshamKaleab Asres
Dec 15, 2015·Chemistry & Biodiversity·Hong ZhuMin-Hui Li
Dec 31, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hossein Maleki-GhalehMir Ghasem Hosseini

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