Aldose reductase, oxidative stress, and diabetic mellitus.

Frontiers in Pharmacology
Wai Ho TangJohn Hwa

Abstract

Diabetes mellitus (DM) is a complex metabolic disorder arising from lack of insulin production or insulin resistance (Diagnosis and classification of diabetes mellitus, 2007). DM is a leading cause of morbidity and mortality in the developed world, particularly from vascular complications such as atherothrombosis in the coronary vessels. Aldose reductase (AR; ALR2; EC 1.1.1.21), a key enzyme in the polyol pathway, catalyzes nicotinamide adenosine dinucleotide phosphate-dependent reduction of glucose to sorbitol, leading to excessive accumulation of intracellular reactive oxygen species (ROS) in various tissues of DM including the heart, vasculature, neurons, eyes, and kidneys. As an example, hyperglycemia through such polyol pathway induced oxidative stress, may have dual heart actions, on coronary blood vessel (atherothrombosis) and myocardium (heart failure) leading to severe morbidity and mortality (reviewed in Heather and Clarke, 2011). In cells cultured under high glucose conditions, many studies have demonstrated similar AR-dependent increases in ROS production, confirming AR as an important factor for the pathogenesis of many diabetic complications. Moreover, recent studies have shown that AR inhibitors may be able to pr...Continue Reading

Citations

Sep 11, 2013·PloS One·Antonella Del-CorsoUmberto Mura
Jul 16, 2014·Journal of Diabetes Research·Liang-Jun Yan
Jun 20, 2012·Journal of Cardiovascular Translational Research·Mona SedeekRhian M Touyz
May 3, 2014·Expert Opinion on Drug Metabolism & Toxicology·Nick Giannoukakis
Aug 4, 2015·Journal of Clinical Biochemistry and Nutrition·Mona S Ottum, Anahita M Mistry
Jan 28, 2016·Aging and Disease·Xiaoting LuoLiang-Jun Yan
Jul 21, 2015·Journal of Proteomics·Indu ChoudharyEuikyung Kim
Jul 6, 2013·Journal of Ethnopharmacology·Venu SankeshiT Naga Raju
Dec 3, 2014·Phytochemistry·Ulrike GrienkeJudith M Rollinger
Dec 30, 2014·Chemico-biological Interactions·Anson SnowJ Mark Petrash
Aug 27, 2013·Cell Metabolism·Katrien De BockPeter Carmeliet
Mar 31, 2015·Oxidative Medicine and Cellular Longevity·Sergio Rosales-CorralRussel J Reiter
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Graciliana LopesPatrícia Valentão
May 22, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jiaquan LuoKai Cao
Jul 18, 2017·International Journal of Molecular Sciences·Subbroto Kumar SahaSsang-Goo Cho
Mar 9, 2018·The Journal of Experimental Biology·Luc Tappy
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Leonid M ZukinJ Mark Petrash
Sep 27, 2018·International Journal of Environmental Research and Public Health·Yoona Kim, Peter Clifton
Sep 30, 2016·Journal of the American Heart Association·Rene BaudrandLuminita H Pojoga
Jan 19, 2019·Phytotherapy Research : PTR·Vânia Ortega GutierresIguatemy Lourenço Brunetti
Feb 15, 2019·Expert Opinion on Therapeutic Patents·Luca Quattrini, Concettina La Motta
Jun 2, 2017·The Open Medicinal Chemistry Journal·Maria DigiacomoSimona Rapposelli
Jun 13, 2019·Journal of the American Heart Association·Diem H Tran, Zhao V Wang
Nov 20, 2019·Canadian Journal of Physiology and Pharmacology·Mutlu SarikayaNet Daş Evcimen
Oct 3, 2018·Current Medicinal Chemistry·Sonia RochaMarisa Freitas

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BETA
transgenic
transfection

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