Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells

FEBS Letters
Kota V RamanaSatish K Srivastava

Abstract

In this study, we examined the role of aldose reductase (AR) in regulating the cytotoxic effects of TNF-alpha on human umbilical vein endothelial cells. Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR abrogated AP-1 DNA binding activity and prevented the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNF-alpha. Exposure to TNF-alpha also induced apoptotic cell death, which was attenuated by AR inhibition or antisense ablation. These observations suggest that AR is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells.

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Citations

Mar 17, 2011·Angiogenesis·Ravinder TammaliKota V Ramana
Mar 13, 2013·Apoptosis : an International Journal on Programmed Cell Death·Weirong WangYanxiang Li
Apr 23, 2009·The Journal of Biological Chemistry·David R D'SouzaAntonino Passaniti
Feb 22, 2011·Chemico-biological Interactions·Umesh C S YadavSatish K Srivastava
May 7, 2011·Biomolecular Concepts·Kota V Ramana
Feb 16, 2007·Cancer Letters·Ravinder TammaliSatish K Srivastava
Mar 27, 2007·Free Radical Biology & Medicine·Kota V RamanaSatish K Srivastava
Jun 29, 2007·International Journal of Cancer. Journal International Du Cancer·Ruilan YanDeliang Cao
Mar 24, 2006·FEMS Immunology and Medical Microbiology·Andrzej GórskiRyszard Miedzybrodzki
Aug 12, 2010·FEMS Immunology and Medical Microbiology·Sławomir LetkiewiczAndrzej Górski
Sep 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Umesh C S YadavSatish K Srivastava
Jul 17, 2019·Biomarkers in Cancer·Ruchika PokhriyalGururao Hariprasad
Jan 16, 2015·American Journal of Physiology. Cell Physiology·Yinfang WangPeng Zhang
Aug 7, 2021·Metabolites·Jonathan Mark PetrashDavid J Orlicky
Mar 1, 2011·Chemico-biological Interactions·Satish K SrivastavaKota V Ramana

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