Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species

Endocrinology
Emilie PastelAnne-Marie Lefrançois-Martinez

Abstract

Aldose reductases (AKR1B) are widely expressed oxidoreductases whose physiological function remains elusive. Some isoforms are genuine prostaglandin F2α (PGF2α) synthases, suggesting they might influence adipose homeostasis because PGF2α inhibits adipogenesis. This was shown by Akr1b7 gene ablation in the mouse, which resulted in increased adiposity related to a lower PGF2α content in fat. Yet humans have no ortholog gene for Akr1b7, so the role of aldose reductases in human adipose homeostasis remains to be explored. We analyzed expression of genes encoding human and mouse aldose reductase isoforms in adipose tissues and differentiating adipocytes to assess conserved mechanisms regulating PGF2α synthesis and adipogenesis. The Akr1b3 gene encoded the most abundant isoform in mouse adipose tissue, whereas Akr1b7 encoded the only isoform enriched in the stromal vascular fraction. Most mouse aldose reductase gene expression peaked in early adipogenesis of 3T3-L1 cells and diminished with differentiation. In contrast with its mouse ortholog Akr1b3, AKR1B1 expression increased throughout differentiation of human multipotent adipose-derived stem cells, paralleling PGF2α release, whereas PGF2α receptor (FP) levels collapsed in early d...Continue Reading

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Citations

Aug 9, 2016·Frontiers in Endocrinology·Emilie PastelA Marie Lefrançois-Martinez
Apr 22, 2017·Toxicon : Official Journal of the International Society on Toxinology·S S SantosD F Silva
Jun 3, 2021·International Journal of Molecular Sciences·Yingxia SongYuji Ishii
Jun 3, 2021·Metabolites·Junichi FujiiMotoko Takahashi

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