Aldosterone renin ratio and chronic kidney disease

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Wessam OsmanIssa Al Salmi

Abstract

As a component of the metabolic syndrome, hypertension (HTN) is increasing throughout the world with variable percentages, but mostly among developing world. Aldosterone plays a role in the relationship between aldosterone and nephropathy. We aimed to evaluate the relationship between aldosterone renin ratio (ARR) and chronic kidney disease (CKD). Variables drawn from the computerized hospital information database were all patients who had an ARR above 35 (if aldosterone reading was above 300 pmol/L). A total of 1584 patients, of whom 777 were male and 807 were female, with a mean [standard deviation (SD)] of 43.3 (16.5) years were studied. The mean ARR was 210.1 (SD: 246.4) in males and 214.3 and 210.1 in females, P = 0.51. The mean estimated glomerular filtration rate (eGFR) was 50.2 (SD 12.6); in males, it was 49.99 (0.90) and in females, it was 50.48 (0.92), P = 0.70. The regression model revealed a negative relationship between ARR and GFR with a coefficient of -2.08, 95% confidence interval: -4.6, 0.21, P = 0.07. CKD population with HTN tends to have a very high level of ARR, and those with advanced CKD have higher ARR. However, high ARR could have low eGFR and kidney dysfunction on follow-up. In view of high prevalence o...Continue Reading

References

May 27, 2003·Diabetes Care·Jawad A Al-LawatiPekka Jousilahti
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·John M FlackErrol Crook
Apr 27, 2004·Journal of Hypertension·Patricia M KearneyJiang He
Jan 18, 2005·Lancet·Patricia M KearneyJiang He
Apr 6, 2005·Trends in Endocrinology and Metabolism : TEM·GianPaolo RossiJohn W Funder
Aug 17, 2005·The Journal of Clinical Hypertension·Camila ManriqueJames R Sowers
Jan 11, 2008·Journal of the American Society of Nephrology : JASN·Yoshio TeradaSei Sasaki
May 12, 2009·The Medical Clinics of North America·Camila ManriqueJames R Sowers
Jan 23, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N SchuppH Stopper
Oct 23, 2010·Journal of the American Society of Nephrology : JASN·Caroline S FoxRamachandran S Vasan
Jan 5, 2011·Nephron. Clinical Practice·Timothy J Ellam, Meguid El Nahas
Oct 26, 2011·Current Vascular Pharmacology·Vanessa RonconiGilberta Giacchetti
Jul 19, 2012·Annals of the New York Academy of Sciences·Marco BoscaroVanessa Ronconi
Oct 30, 2012·Free Radical Biology & Medicine·Nina QueisserNicole Schupp
Dec 4, 2013·Nature Reviews. Nephrology·Sara S RoscioniDick de Zeeuw
Jul 6, 2014·Current Opinion in Nephrology and Hypertension·James M Luther
Nov 18, 2015·Current Opinion in Nephrology and Hypertension·James M Luther
Nov 26, 2015·American Journal of Nephrology·Anna J JovanovichUNKNOWN HOST Investigators
Jan 9, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Krishna K KadappuLiza Thomas
Jun 7, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin QuachMichael Walsh
Nov 9, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alison G AbrahamAlvaro Muñoz
Dec 20, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Faissal A M ShaheenUNKNOWN GCC-DOPPS 5 Study Group
Dec 22, 2017·BMC Nephrology·Christina M GantUNKNOWN Holland Nephrology Study (HONEST) Network

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Samantha Alvarez-MadrazoJohn M C Connell
Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Katharina SchilbachM Bidlingmaier
Journal of the Renin-angiotensin-aldosterone System : JRAAS
Christina WesterdahlStig Valdemarsson
© 2021 Meta ULC. All rights reserved