Aldosterone responses to hyperkalemia in healthy elderly humans.

Journal of the American Society of Nephrology : JASN
E MulkerrinB A Clark

Abstract

Plasma aldosterone levels are reported to be lower in healthy elderly individuals compared with young individuals, a difference exaggerated by sodium depletion or upright posture. The aim of this study was to determine the aldosterone response to increases in serum potassium with advancing age. In the Clinical Research Center, six healthy young (20 to 35 yr of age) and six healthy elderly (65 to 85 yr of age) subjects underwent evaluation of their aldosterone responses to potassium infusion (0.5 mEq/kg over 45 min). Both young and elderly subjects had similar basal serum potassium levels (4.3 +/- 0.2 versus 4.4 +/- 0.1 mEq/L), similar sodium and potassium excretion amounts and similar increase in serum potassium levels during infusion (to 5.0 +/- 0.2 versus 5.1 +/- 0.1 mEq/L). However, elderly subjects had lower basal levels of plasma aldosterone and a blunted aldosterone response to potassium infusion (P < 0.05, analysis of variance). Advancing age is characterized by relative hypoaldosteronism in the basal state as well as in response to hyperkalemia. This may contribute to an increased susceptibility to hyperkalemia if other potassium regulatory systems fail.

Citations

Nov 5, 1997·Journal of General Internal Medicine·M A Perazella, R L Mahnensmith
Dec 13, 2017·Hypertension·Kazutaka NanbaWilliam E Rainey
Feb 25, 2005·QJM : Monthly Journal of the Association of Physicians·A FlynnE C Mulkerrin
Jul 2, 2021·European Journal of Heart Failure·Marco TrevisanJuan J Carrero
Apr 6, 2021·Aging and Disease·Yu-Hsiang Chou, Yung-Ming Chen
Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Phuong-Chi T PhamPhuong-Thu T Pham
Jan 25, 2008·Journal of the American Society of Nephrology : JASN·Leslie Thomas, Rajiv Kumar
Feb 12, 2008·The Journal of Nutrition, Health & Aging·C Mc GreevyE C Mulkerrin
Mar 23, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Uta CeglarekJuergen Kratzsch
Apr 20, 2010·Néphrologie & thérapeutique·Bertrand Dussol

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