Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium

Journal of the American Society of Nephrology : JASN
Yoshio TeradaSei Sasaki

Abstract

Several recent reports support the hypothesis that aldosterone contributes to the progression of renal injury. Mineralocorticoids increase the expression of serum- and glucocorticoid-inducible protein kinase 1 (SGK1), which is upregulated in several fibrotic diseases. It was hypothesized that SGK1 may mediate the effects of aldosterone on glomerular fibrosis and inflammation. In primary cultures of rat mesangial cells, aldosterone stimulated the expression, phosphorylation, and kinase activity of SGK1, as well as SGK1-dependent NF-kappaB activity. Furthermore, aldosterone augmented the promoter activity and protein expression of intercellular adhesion molecule-1 (ICAM-1), which modulates the inflammatory response, and the profibrotic cytokine connective tissue growth factor (CTGF) in an SGK1- and NF-kappaB-dependent manner. Similar to the in vitro results, uninephrectomized rats that were treated with aldosterone demonstrated increased glomerular expression of SGK1, ICAM-1, and CTGF proteins than untreated rats; these changes were accompanied by hypertension, glomerulosclerosis, and inflammation. In conclusion, these findings suggest that aldosterone stimulates ICAM-1 and CTGF transcription via the activation of SGK1 and NF-kap...Continue Reading

References

Aug 1, 1985·The Journal of Clinical Investigation·S AndersonB M Brenner
Feb 1, 1994·Kidney International·M E RosenbergT H Hostetter
May 1, 1993·Journal of Molecular and Cellular Cardiology·C G BrillaK T Weber
Aug 15, 1996·The Journal of Clinical Investigation·E L GreeneT H Hostetter
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S WaldeggerF Lang
Apr 29, 1998·Kidney International·Y ItoR Goldschmeding
Jun 8, 1999·The Journal of Biological Chemistry·A Náray-Fejes-TóthG Fejes-Tóth
Dec 10, 1999·The Journal of Biological Chemistry·O KranenburgW H Moolenaar
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·F LangS Broër
Sep 26, 2000·Molecular Genetics and Metabolism·E E Moussad, D R Brigstock
Jul 28, 2001·Kidney International·Y TeradaF Marumo
Sep 22, 2001·The New England Journal of Medicine·A Chrysostomou, G Becker
Mar 27, 2002·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sophie FillonFlorian Lang
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Jianghui HouRoger W Brown
Jun 22, 2002·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Simone WaerntgesFlorian Lang
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Alan N CharneyGurdip S Sidhu
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Omar A ItaniChristie P Thomas
Nov 6, 2002·The Journal of Clinical Investigation·Peer WulffDietmar Kuhl
Nov 19, 2002·Kidney & Blood Pressure Research·B FriedrichF Lang
Jun 25, 2005·Journal of the American Society of Nephrology : JASN·Yoshio TeradaSei Sasaki
Apr 11, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Volker VallonFlorian Lang
Aug 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ferruh ArtuncFlorian Lang

❮ Previous
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Citations

Mar 18, 2010·Nature Reviews. Nephrology·Marie Briet, Ernesto L Schiffrin
Jul 9, 2009·Current Opinion in Nephrology and Hypertension·Florian LangVolker Vallon
May 28, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Brenna G NewfellIris Z Jaffe
Nov 7, 2008·Journal of the American Society of Nephrology : JASN·Valérie LeroyEric Féraille
Mar 24, 2012·Journal of the American Society of Nephrology : JASN·Wakako KawarazakiToshiro Fujita
Jul 9, 2013·Clinical and Experimental Nephrology·Kohei Ueda, Miki Nagase
Nov 13, 2010·Clinical and Experimental Nephrology·Seiichi FukudaMatsuhiko Hayashi
Feb 22, 2012·Clinical and Experimental Nephrology·Katsumasa Kawahara, Kouju Kamata
Mar 20, 2013·Expert Opinion on Investigational Drugs·Florian Lang, Jakob Voelkl
Jan 22, 2010·Revista española de cardiología·Julián RoldánVicente Bertomeu
Jun 28, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew S BremRujun Gong
May 23, 2012·Free Radical Biology & Medicine·Nina Queisser, Nicole Schupp
Oct 28, 2014·Frontiers in Endocrinology·Rabi YacoubJohn Cijiang He
Dec 5, 2014·Pflügers Archiv : European journal of physiology·Katrina J BingerMarkus Kleinewietfeld
Dec 28, 2010·Journal of Pharmacological Sciences·Kazi RafiqAkira Nishiyama
Jan 20, 2009·Journal of Pharmacological Sciences·Akira NishiyamaHideyasu Kiyomoto
May 18, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Magdalena PawlikPaweł P Jagodziński
Jan 2, 2009·Journal of the American Society of Nephrology : JASN·Nancy J Brown
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Armin Just
Mar 5, 2010·American Journal of Physiology. Renal Physiology·Andrew S BremRujun Gong
Sep 4, 2015·American Journal of Physiology. Renal Physiology·Narihito TatsumotoTakanari Kitazono
Apr 12, 2011·Renal Failure·Christos BantisKatrin Ivens
Feb 27, 2009·American Journal of Physiology. Renal Physiology·Femke WaandersJan-Luuk Hillebrands
Mar 5, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Wessam OsmanIssa Al Salmi
Mar 8, 2014·Nephron. Experimental Nephrology·Shigetaka YoshidaMiki Nagase
Nov 13, 2020·Drug Development Research·Vishal PatelMukul Jain
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Florian LangMadhuri S Salker
Feb 16, 2021·American Journal of Physiology. Renal Physiology·Catalina Sierra-RamosDiego Alvarez de la Rosa
Dec 29, 2020·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Sara ErraezPablo Gómez-Fernández
Sep 5, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Sara ErraezPablo Gómez-Fernández
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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