Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon

The American Journal of Physiology
J H ChoE B Chang

Abstract

Na+ retention by the colon in response to salt deprivation is mediated in part by the resulting secondary hyperaldosteronism. We show that experimental hyperaldosteronism, to levels seen with salt deprivation, causes an increase in the selective expression and activity of NHE3, an apically located isoform of the Na+/H+ exchange family that functions in transepithelial Na+ absorption. The effect of aldosterone on NHE3 expression is tissue specific, occurring in intestine and not in kidney. Within the intestine, these effects are regional, being observed only in proximal colon, and different in distribution from that observed with glucocorticoids, where the predominant effect occurs in ileum. Although glucocorticoids are well known to exert many effects via regulation of transcript levels, the present study demonstrates that aldosterone stimulates intestinal Na+ absorption by increasing cellular NHE3 expression, a response that is tissue and region specific.

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Citations

Apr 5, 2001·American Journal of Physiology. Cell Physiology·F RochaE B Chang
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M W MuschE B Chang
Dec 26, 2001·The Journal of Biological Chemistry·C Chris YunFlorian Lang
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