Aldosterone upregulates Ca(2+) current in adult rat cardiomyocytes

Circulation Research
Jean-Pierre Benitah, G Vassort

Abstract

Aldosterone is associated with the pathogenesis and progression of left ventricular hypertrophy and heart failure, independent of its relation with arterial blood pressure. However, little information exists about the possible influence of this mineralocorticoisteroid on cardiomyocyte electrical activity. The present study was designed to determine the role of aldosterone on whole-cell Ca(2+) current (I(Ca)) in isolated adult rat ventricular myocytes using the patch-clamp technique. We found that incubation of cells with 1 micromol/L aldosterone for 24 hours increases the density of I(Ca) significantly. This "long-term" aldosterone treatment had no significant effects on the kinetics and voltage dependence of I(Ca) inactivation. Moreover, no demonstrable influence of aldosterone on I(Ca) could be detected during short-term exposure (up to 6 hours), under our experimental conditions. The classical aldosterone intracellular receptor antagonist spironolactone (250-fold excess) was able to blunt the aldosterone-induced increase in I(Ca) density. These effects were also observed with lower concentrations of aldosterone (10 and 100 nmol/L). Moreover, inhibitors of transcription (actinomycin D, 5 microg/mL) and protein synthesis (cycl...Continue Reading

References

Dec 1, 1992·Molecular and Cellular Endocrinology·M WehlingM Christ
Sep 1, 1992·European Heart Journal·C G BrillaK T Weber
Aug 1, 1992·The American Journal of Physiology·R S KievalW J Lederer
Nov 1, 1987·Clinical and Experimental Pharmacology & Physiology·P Pearce, J W Funder
Jan 1, 1966·Endocrinology·G SayersG R Nadzam
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Nov 1, 1995·Journal of Molecular and Cellular Cardiology·I KorichnevaG Vassort
Jan 1, 1996·Basic Research in Cardiology·S R Holmer, H Schunkert
Jan 1, 1997·Annual Review of Physiology·M Wehling
Feb 28, 1998·Journal of Molecular and Cellular Cardiology·M A HeftiM C Schaub
Feb 12, 1998·The American Journal of Physiology·A S MihailidouH H Rasmussen
Mar 28, 1998·The Journal of Biological Chemistry·J S SilvestreC Delcayre
Aug 5, 1998·The American Journal of Physiology·T KrarupE K Hoffmann
Jun 1, 1963·The American Journal of Physiology·W C ULLRICK, R L HAZELWOOD

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Citations

Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Claude Delcayre, Bernard Swynghedauw
Nov 28, 2007·Pflügers Archiv : European journal of physiology·Jean-Sébastien RougierHugues Abriel
Nov 20, 2008·Pflügers Archiv : European journal of physiology·Michael Gekle, Claudia Grossmann
Dec 3, 2009·Pflügers Archiv : European journal of physiology·Michael WagnerTilmann Volk
May 12, 2004·Molecular and Cellular Endocrinology·C HeymesC Delcayre
May 12, 2004·Molecular and Cellular Endocrinology·Melyssa R BrattonJose S Subauste
Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Michel F RossierNathalie Lalevée
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·R Rocha, C T Stier
Nov 21, 2001·Current Opinion in Pharmacology·E G McMahon
Mar 29, 2005·Nature Medicine·Rong ZhangMark E Anderson
Oct 2, 2008·Cardiovascular Research·Georghia MichaelStanley Nattel
Feb 16, 2012·Cardiovascular Research·Andreas TomaschitzStefan Pilz
May 8, 2013·Clinical and Experimental Pharmacology & Physiology·Valeria KrandychevaDmitry Shmakov
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Saori MatsuiHideharu Hayashi
Jun 16, 2011·PloS One·María Fernández-VelascoJean-Pierre Benitah
Apr 4, 2002·Drugs·Ricardo Rocha, Gordon H Williams
Mar 26, 2014·Journal of Cardiovascular Pharmacology·Joachim AlexandrePaul Milliez
Jul 15, 2009·Journal of Cardiovascular Pharmacology·Junko Kurokawa, Hugues Abriel
May 28, 2003·Journal of Cellular and Molecular Medicine·A M Katz
Dec 15, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Katrin KlicheHans Oberleithner
Sep 17, 2005·The Journal of Physiology·Romain PerrierJean-Pierre Bénitah
Jan 13, 2011·The Journal of Physiology·Guojun ChenGuy Salama
Nov 17, 2001·The Journal of Physiology·J P BénitahG Vassort
Oct 9, 2012·Trends in Endocrinology and Metabolism : TEM·B Julie He, Mark E Anderson
May 12, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bruce S StamblerNichole L Martovitz
Apr 28, 2009·Experimental Physiology·Beatriz Martin-FernandezCarmen Delgado
Aug 16, 2005·The Journal of Laboratory and Clinical Medicine·Aliye L RunyanKarl T Weber
Feb 10, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Shahriar Iravanian, Samuel C Dudley
May 17, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bernard SwynghedauwPaul Milliez
Jan 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ana M GómezAchilles J Pappano

❮ Previous
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