Alemtuzumab for relapsing multiple sclerosis in clinical practice: A four-year retrospective one-center study.

The International Journal of Risk & Safety in Medicine
Belén Rodríguez de CastroCristina Martínez-Múgica Barbosa

Abstract

Disease-modifying therapies for multiple sclerosis have been developed tremendously over the last two decades. The aim of this study was to review the short-, medium-, and long-term safety of alemtuzumab in relapsing remitting multiple sclerosis (RRMS). This retrospective observational study (2015-2019) included all patients with highly active or rapidly progressing and aggressive RRMS who were treated with alemtuzumab at the Cabueñes University Hospital. The short-, medium-, and long-term adverse effects were evaluated following the risk management program of the European Medicines Agency. 39 patients were included, 23 of them received at least two cycles of treatment. Most patients showed at least one adverse event. The following adverse reactions were reported: infusional reactions (17), urinary tract infections (six), thrombopenia (five), and thyroid dysfunction (six). In clinical practice alemtuzumab showed an acceptable safety profile in selected patients even if all of them suffered at least one adverse effect. Thorough and prolonged follow-up is required to further confirm the safety of this drug.

References

Oct 24, 2008·The New England Journal of Medicine·Alasdair J ColesP K Tandon
May 18, 2012·The New England Journal of Medicine·Gary BloomgrenCarmen Bozic
Feb 18, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Helmut ButzkuevenUNKNOWN TYSABRI Observational Program (TOP) Investigators
Jul 2, 2015·International Journal of Molecular Sciences·Daniela RauAntonios Bayas
Oct 31, 2015·Multiple Sclerosis : Clinical and Laboratory Research·M D WillisN P Robertson
Aug 24, 2016·BMJ : British Medical Journal·Dean M Wingerchuk, Brian G Weinshenker
Jan 29, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Diana L Vargas, William R Tyor
Aug 25, 2017·Neurology·Eva HavrdovaUNKNOWN CARE-MS I and CAMMS03409 Investigators
Aug 25, 2017·Neurology·Alasdair J ColesUNKNOWN CARE-MS II and CAMMS03409 Investigators
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Jan 11, 2018·The New England Journal of Medicine·Daniel S ReichPeter A Calabresi
Mar 27, 2018·Lancet·Alan J ThompsonOlga Ciccarelli

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Citations

Mar 30, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Asta TheodorsdottirZsolt Illes

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