Alemtuzumab treatment for Sézary syndrome: A single-center experience

The Journal of Dermatological Treatment
Silvana NovelliJavier Briones

Abstract

Sézary syndrome (SS) is characterized by rapidly progressive disease and poor survival. Although there is no standard treatment for SS, allogeneic stem cell transplantation (alloSCT) is the only treatment available that may offer a long survival. Alemtuzumab, a humanized monoclonal antibody that targets CD52, has reported some efficacy in this disease. To describe the experience with alemtuzumab treatment in patients with SS in our center. A total of six patients received alemtuzumab subcutaneously at different dosing regimens. The median time of follow-up after alemtuzumab was 6 months (range 3-29 months). The overall response rate was 83.3% (5/6) with 66.7% complete responses. The disease-free survival (DFS) at 6 months was 33.3%. Increased DFS was observed in patients undergoing an alloSCT after alemtuzumab treatment. The overall survival at 6 months was 60%. Alemtuzumab is an effective treatment in advanced mycosis fungoides/SS for palliation of symptoms and may be useful as a bridge therapy before alloSCT in relapsed/refractory patients.

References

Sep 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arturo MolinaAuayporn Nademanee
Apr 5, 2007·Cancer Chemotherapy and Pharmacology·Jong Gwang KimSuk Joong Oh
Feb 13, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J KimW S Kim
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farhad RavandiHagop Kantarjian
Jan 22, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E D JacobsenJ H Antin
Apr 13, 2011·British Journal of Haematology·Anton B AlexandroffMartin J S Dyer
Oct 13, 2011·American Journal of Hematology·Ryan A Wilcox
Jan 21, 2014·The British Journal of Dermatology·A de MassonM Bagot
Nov 29, 2014·The Journal of Investigative Dermatology·Constantijn J M HalkesMaarten H Vermeer

❮ Previous
Next ❯

Citations

Dec 22, 2016·Expert Review of Hematology·Pooja VirmaniPierluigi Porcu
Jul 19, 2019·International Journal of Hematology·Silvana NovelliJorge Sierra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.