Alfacalcidol reduces accelerated bone turnover in elderly women with osteoporosis

Journal of Bone and Mineral Metabolism
Masataka ShirakiTsuneji Nagai

Abstract

To evaluate the effects of alfacalcidol on bone turnover in elderly women with osteoporosis, an open-label, prospective, calcium-controlled study was conducted. A total of 80 patients with osteoporosis were divided into two groups: the control group, group C (mean age, 78.0 years), in which patients were given calcium, and group D (mean age, 77.4 years), in which the patients were given alfacalcidol 1 micro g/day together with calcium for 6 months. Calcium regulation, lumbar bone mineral density (LBMD), and markers for bone turnover were assessed. A significant increase in urinary calcium/creatinine ratio (90% increase from baseline at 3 months; P = 0.0083, and 60% at 6 months; P = 0.0091) and a significant decrease in serum parathyroid hormone (30% decrease from baseline at 6 months; P < 0.0001) was observed in group D compared with the corresponding changes in group C. Significant decreases of bone resorption markers (deoxypyridinoline and N-telopeptide) at 6 months (about 15% decrease from the baseline values) were observed in group D compared with the corresponding changes in group C. The changes in bone formation markers (bone-derived alkaline phosphatase and osteocalcin) in group D were significantly different at 6 months...Continue Reading

Citations

Jan 14, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C-L ShenJ-S Wang
Aug 11, 2012·Endocrinology and Metabolism Clinics of North America·Tomohiko Yoshida, Paula H Stern
May 15, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Birgitta TengstrandJan Tidermark
Dec 12, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Naoyuki Takahashi
Jan 15, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Sep 19, 2007·Journal of Nutritional Science and Vitaminology·Jun IwamotoJames K Yeh
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Jun 24, 2014·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Nov 24, 2011·Archives of Biochemistry and Biophysics·Tatsuo SudaNaoyuki Takahashi

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