PMID: 8949692Sep 1, 1996Paper

Alfentanil as procedural pain relief in newborn infants

Archives of Disease in Childhood. Fetal and Neonatal Edition
E SaarenmaaV Fellman

Abstract

To assess the need for, and the suitability of, alfentanil for pain relief during tracheal suction used in assisted ventilation in newborn infants. In a randomised, controlled, double blind, crossover trial, placebo (10 micrograms/kg) and 20 micrograms/kg alfentanil were infused in random order two minutes before three separate endotracheal suctions, at least six hours apart, to 10 infants. Measurements were made of physiological variables, behaviour, and stress hormones. After placebo infusion heart rate significantly increased (median 14; interquartile range 12-16 beats/minute) as did behavioural pain score (5; 3-5). Alfentanil (20 micrograms/kg) attenuated the heart rate increase, normalised the pain score, and caused a decrease in plasma adrenaline activity (0.3; 0.2-0.7 nmol/l). Noradrenaline concentration showed a nonsignificant decreasing trend with increasing alfentanil dose and beta endorphin was unchanged. Rigidity was noted in the placebo (n = 2), 10 micrograms/kg (n = 2), and 20 micrograms/kg (n = 5) alfentanil groups, respectively. Tracheal suction is a painful procedure. The dose of alfentanil required for pain relief (20 micrograms/kg) causes a high incidence of rigidity and thus should be used only with muscle r...Continue Reading

References

Apr 1, 1992·Archives of Disease in Childhood·D T Gault
Aug 1, 1992·Anesthesia and Analgesia·M L PokelaA L Saukkonen
Jan 1, 1990·Developmental Pharmacology and Therapeutics·A KillianR D Guthrie
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Jul 1, 1981·Acta Physiologica Scandinavica·O VuolteenahoN Ling

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Citations

Apr 1, 2009·The Clinical Journal of Pain·Anna AxelinLiisa Lehtonen
Aug 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Brenda M Morrow, Andrew C Argent
Oct 24, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·K J S Anand, R W Hall
Jun 23, 2001·Archives of Disease in Childhood. Fetal and Neonatal Edition·E SaarenmaaV Fellman
Jan 22, 2010·Pediatric Research·Xavier DurrmeyerPeter C Rimensberger
Dec 3, 2014·Clinics in Perinatology·Richard W Hall, Kanwaljeet J S Anand
Oct 2, 2007·Seminars in Perinatology·R Whit HallThomas Young
Feb 11, 2005·Seminars in Fetal & Neonatal Medicine·D TibboelJ N van den Anker
Jan 19, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·R Carbajal
Aug 25, 2005·Clinical Therapeutics·K J S AnandGary A Walco
Aug 25, 2005·Clinical Therapeutics·K J S AnandGary A Walco
Apr 28, 2005·Expert Review of Neurotherapeutics·Ricardo CarbajalDaniel Annequin
Feb 7, 2008·The Cochrane Database of Systematic Reviews·R BellùR Zanini

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