Algae extract protection effect on oxidized protein level in human stratum corneum

Annals of the New York Academy of Sciences
Carine NizardBertrand Friguet

Abstract

Modification of proteins by reactive oxygen species is implicated in different disorders. The proteasome is a multicatalytic proteinase in charge of intracellular protein turnover and of oxidized proteins degradation. Consequently, proteasome function is very important in controlling the level of altered proteins in eukaryotic cells. Evidence for a decline in proteasome activity during skin photo-aging has been provided in Bulteau et al. in 2002. The ability of a lipid algae extract (Phaeodactylum tricornutum) to stimulate 20S proteasome peptidase activities was described by Nizard et al. in 2001. Furthermore, keratinocytes treated with Phaeodactylum tricornutum extract and then UVA and UVB irradiated, exhibited a sustained level of proteasome activity comparable to the one of nonirradiated cells. The level of modified proteins can be quantified by measurement of protein carbonyl content (Oxyblot technique), which has been shown to increase with aging and other disorders. In this paper, it is described that, in the presence of this lipid algae extract, the level of oxidized proteins is reduced, as assessed by the Oxyblot technique. These results are obtained both with culture of human keratinocytes and stratum corneum skin cell...Continue Reading

References

Aug 15, 1997·The Journal of Biological Chemistry·B S Berlett, E R Stadtman
Dec 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·K K NiyogiA R Grossman
Jun 22, 2001·Radiation Research·R M Moison, G M Beijersbergen Van Henegouwen
May 29, 2002·Free Radical Biology & Medicine·Anne-Laure BulteauBertrand Friguet

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Citations

Feb 21, 2006·Antioxidants & Redox Signaling·Diana Poppek, Tilman Grune
Feb 21, 2006·Antioxidants & Redox Signaling·Luc Farout, Bertrand Friguet
Oct 31, 2012·Molecular Aspects of Medicine·Niki ChondrogianniEfstathios S Gonos
Jul 1, 2007·Aesthetic Surgery Journal·Catherine K Huang, Timothy A Miller
Jun 15, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing-Iong YangHsueh-Wei Chang
Sep 21, 2006·Free Radical Research·Peter VossTilman Grune
Apr 27, 2007·Annals of the New York Academy of Sciences·Anne-Laure BulteauBertrand Friguet
Mar 1, 2021·Redox Biology·Mary Α VasilopoulouNiki Chondrogianni

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