Algal fucoidan, unlike heparin, has thrombolytic activity in a murine arterial thrombosis model

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Soon-Ki MinJong-Ki Kim

Abstract

Thrombolytic effects of fucoidans were investigated in the FeCl3-induced arterial thrombus mouse model and compared with heparin and tissue plasminogen activator (t-PA). Thrombosis model was made by applying 5% FeCl3 on the carotid artery of a Balb/c mouse. Twenty minutes after complete occlusion, a couple of test agents including fucoidan were infused into each mouse group with various doses intravenously, before measuring the time to reperfusion. The occluded arteries were reperfused 37.5 ± 12.4 min after administration of unfractionated fucoidan from Undaria pinnatifida sporophylls (UPS-UF) with a dose of 100 mg/kg. In the mice given either a low-molecular-weight UPS fucoidan or fucoidan source from Fucus vesiculosus (FV-UF), reperfusion was delayed at 55.0 ± 8.0 min with a higher reperfusion effective dose (RED) of 1 g/kg or at 63.3 ± 7.2 at RED of 200 mg/kg, respectively. In the control mice given t-PA of 15 mg/kg, reperfusion occurred at 24.8 ± 6.5 min after administration. In contrast, reperfusion was not observed in the occluded mice given heparin (P < 0.001) in the range of 60-1000 mg/kg. Minimal injection of fucoidan in addition to a given t-PA-enabled restoration of blood flow in the blocked artery without reocclusio...Continue Reading

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Citations

Feb 1, 2013·BMC Complementary and Alternative Medicine·M Atiar RahmanChowdhury Mohammad Monirul Hasan
Sep 9, 2015·Glycobiology·Mikhail I KusaykinTatyana N Zvyagintseva
Jul 22, 2015·Journal of Medicinal Food·Don-Gil LeeTae-Hoo Yi
Jul 2, 2016·Pharmacognosy Research·Raju DashMir Muhammad Nasir Uddin
Feb 2, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Soon-Ki MinJong-Ki Kim
Aug 1, 2018·Marine Drugs·Marcelo D CatarinoSusana M Cardoso

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