Algesia and local responses induced by neurokinin A and substance P in human skin and temporal muscle.

Peptides
U Pedersen-BjergaardJ Olesen

Abstract

Neurokinin A (NKA), substance P (SP) and the two peptides combined (SP + NKA) were injected intracutaneously on the forearm and into the temporal muscle of healthy volunteers. Pain intensity, cutaneous wheal and flare responses and tenderness of the temporal muscle were quantitated. SP but not NKA induced cutaneous pain. This relates the algesic effect of SP to the specific N-terminal amino acid sequence of the peptide, not shared by NKA. NKA, however, potentiated the algesic effect of SP as SP + NKA induced a significantly prolonged cutaneous pain sensation. Both peptides induced wheals, but only SP induced flare. These results confirm previous studies relating wheal formation to the identical C-terminal amino acid sequence of the two peptides and flare reaction to the N-terminal part of SP. Injections into the temporal muscle did not cause pain or tenderness.

References

Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·W Piotrowski, J C Foreman
Oct 1, 1986·Canadian Journal of Physiology and Pharmacology·M I Sweeney, J Sawynok
Apr 23, 1987·Neuroscience Letters·K SaitoM A Moskowitz
Feb 1, 1988·British Journal of Clinical Pharmacology·T W EvansP J Barnes
Feb 1, 1988·Agents and Actions·J Szolcsányi
Dec 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·X HuaE Brodin
Apr 1, 1981·Acta Physiologica Scandinavica·E BrodinL Olgart
Aug 1, 1984·Annals of Neurology·M A Moskowitz

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Citations

May 1, 1994·Trends in Pharmacological Sciences·J OlesenH Iversen
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jan 1, 1997·European Journal of Pain : EJP·R J LaursenL Arendt-Nielsen
Apr 6, 2001·The Clinical Journal of Pain·L Arendt-Nielsen, P Svensson
May 3, 2013·PLoS Neglected Tropical Diseases·Camila GewehrMarcus V Gomez
Jun 19, 2009·Nature Chemical Biology·Aled M EdwardsTimothy M Willson
May 11, 2010·The Journal of Headache and Pain·Henrik Winther SchytzMessoud Ashina
Jul 2, 2010·British Journal of Pharmacology·A Bilkei-GorzoA Zimmer
Dec 31, 1997·Neuropeptides·H HolthusenZ P Ding
Aug 1, 1994·Journal of the American College of Cardiology·A GaspardoneP A Gioffrè
Sep 1, 1991·Cephalalgia : an International Journal of Headache·K JensenI Jansen
Apr 3, 2019·International Journal of Molecular Sciences·Chu-Ting ChangChih-Cheng Chen
Apr 17, 2019·CNS Drugs·Kristian Agmund Haanes, Lars Edvinsson

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