Alginate beads as a carrier for omeprazole/SBA-15 inclusion compound: A step towards the development of personalized paediatric dosage forms

Carbohydrate Polymers
Pasquale Del GaudioStefano Giovagnoli

Abstract

The treatment of gastro-esophageal reflux disease (GERD) shows several issues among paediatric patients. This work aims to the formulation of enteric alginate beads loaded with omeprazole (OME) allowing age- and weight-related personalized dosages in children. OME was entrapped in SBA-15 mesoporous compound, characterized and loaded into alginate beads by prilling at different OME and alginate concentrations. The beads resulted of homogeneous size, spherical morphology and very consistent in drug loading and distribution. Formulations demonstrated limited swelling and release (about 10%) in simulated gastric fluid (SGF) after 2h and a prolonged release in simulated intestinal fluid (SIF), till 6h, due to a mixed diffusion-case II transport mechanism. The beads were superior to the market product, which showed lower release in SGF but immediate dissolution in SIF. The high alginate beads uniformity and release properties make them a potential novel tool for a personalized treatment of GERD in children.

References

Mar 18, 1999·The New England Journal of Medicine·J LagergrenO Nyrén
Jun 8, 2001·Clinical Therapeutics·A E ZimmermannD Levine
Mar 8, 2003·International Journal of Pharmaceutics·Kosmas KosmidisPanos Macheras
Jul 13, 2004·Drug Development and Industrial Pharmacy·Harmik SohiRoop K Khar
Aug 17, 2005·International Journal of Pharmaceutics·Pasquale Del GaudioFabio Sonvico
May 18, 2007·International Journal of Pharmaceutics·Raida S Al-KassasMonirah M Al-Faadhel
Aug 7, 2007·Digestive Diseases and Sciences·V Tolia, K Boyer
Aug 28, 2007·Journal of Pharmaceutical Sciences·Stefano GiovagnoliCarlo Rossi
Sep 11, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·V AmbrogiC Rossi
Nov 3, 2007·Pediatrics·Vikram KhoshooMitchell Rubin
Apr 29, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica M Rosenholm, Mika Lindén
May 13, 2008·Gastroenterology·Les Lang
Oct 28, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Aurélie SchoubbenMaurizio Ricci
Nov 29, 2008·Journal of Pharmaceutical and Biomedical Analysis·Fabio S MurakamiMarcos A S Silva
Oct 27, 2009·AAPS PharmSciTech·Pasquale Del GaudioRita P Aquino
Dec 23, 2009·International Journal of Pharmaceutics·M J K ThomasD Douroumis
Sep 29, 2011·Journal of Pediatric Gastroenterology and Nutrition·Ii-Lun ChenDonna Griebel
Dec 27, 2011·Journal of Pediatric Gastroenterology and Nutrition·Chao-Hua ChuangYi Chun Chen
Mar 1, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Valeria AmbrogiCarlo Rossi
Mar 1, 2012·World Journal of Gastrointestinal Pathophysiology·Naoaki SakataMichiaki Unno
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Aug 15, 2013·International Journal of Pharmaceutics·Benedicte M Ricci
Sep 4, 2013·Advanced Drug Delivery Reviews·Jenny K W LamIan C K Wong
Dec 5, 2013·Carbohydrate Polymers·Felicetta De CiccoPasquale Del Gaudio
Jan 9, 2014·Nature Medicine·Elie Dolgin
Mar 4, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pasquale Del GaudioRita Patrizia Aquino
Jul 1, 2014·International Journal of Pharmaceutics·Felicetta De CiccoPasquale Del Gaudio

❮ Previous
Next ❯

Citations

May 31, 2016·Drug Development and Industrial Pharmacy·Andrea CercielloRita P Aquino
Apr 12, 2016·Chemical Biology & Drug Design·Mostafa MohammadzadehSina Omid Malayeri
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Mahnaz AmiriAhmad Akbari
Jul 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giulia AuriemmaRita Patrizia Aquino
Jul 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francesca SansoneRita Patrizia Aquino
Mar 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosalía Rodríguez-DoradoPasquale Del Gaudio
Jan 18, 2018·International Journal of Pharmaceutics·Rosalia Rodríguez-DoradoPasquale Del Gaudio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wei sheng yan jiu = Journal of hygiene research
Yinghua LiXiaoguang Yang
The American Journal of Gastroenterology
B E SchenkS G Meuwissen
© 2021 Meta ULC. All rights reserved