Alginate hydrogel beads as a carrier of low density lipoprotein/pectin nanogels for potential oral delivery applications

International Journal of Biological Macromolecules
Mingyong ZhouYangchao Luo

Abstract

Alginate hydrogel beads have been extensively investigated as drug delivery systems due to promising gastric environment stability. In the present study, alginate hydrogel beads were prepared with Ca2+ or Fe3+ to serve as the loading vehicles for egg yolk low density lipoprotein (LDL)/pectin nanogels. Scanning electron microscope was carried out to confirm the successful incorporation of nanogels into the beads. The FT-IR spectra and swelling ratio analyses proved that incorporation of nanogels did not affect the physicochemical properties of the hydrogel beads. The developed hydrogel beads exhibited pH dependent release of curcumin pre-encapsulated in nanogels, with significant retention of curcumin in gastric condition compared to curcumin encapsulated in nanogels or alginate beads alone. Hydrogel beads prepared with low viscous alginate and Ca2+ showed limited swelling property and more sustained release of curcumin in simulated gastrointestinal conditions, compared to the beads prepared with high viscous alginate and Fe3+. Gradual dissociation of nanogels from the beads during incubation in simulated intestinal fluid was studied with transmission electron microscope. Our study demonstrated the promising potential of alginat...Continue Reading

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Citations

Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikolas J RodriguezYangchao Luo
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Shizhou WuHockin H K Xu
Aug 2, 2020·International Journal of Biological Macromolecules·Ithiara Dalponte DallabonaRegina Maria Matos Jorge
Aug 25, 2021·International Journal of Biological Macromolecules·Fuyu SongHaisong Wang
Oct 2, 2021·Comprehensive Reviews in Food Science and Food Safety·Duoduo LiChanghu Xue
Oct 26, 2021·Frontiers in Pharmacology·Yanhong WuYantao Han

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