Algorithm for rapid determination of optical scattering parameters

Optics Express
Zachary H LevinePaul Lemaillet

Abstract

Preliminary experiments at the NIST Spectral Tri-function Automated Reference Reflectometer (STARR) facility have been conducted with the goal of providing the diffuse optical properties of a solid reference standard with optical properties similar to human skin. Here, we describe an algorithm for determining the best-fit parameters and the statistical uncertainty associated with the measurement. The objective function is determined from the profile log likelihood, including both experimental and Monte Carlo uncertainties. Initially, the log likelihood is determined over a large parameter search box using a relatively small number of Monte Carlo samples such as 2·104. The search area is iteratively reduced to include the 99.9999% confidence region, while doubling the number of samples at each iteration until the experimental uncertainty dominates over the Monte Carlo uncertainty. Typically this occurs by 1.28·106 samples. The log likelihood is then fit to determine a 95% confidence ellipse. The inverse problem requires the values of the log likelihood on many points. Our implementation uses importance sampling to calculate these points on a grid in an efficient manner. Ultimately, the time-to-solution is approximately six times...Continue Reading

References

Jul 1, 1995·Computer Methods and Programs in Biomedicine·L WangL Zheng
Sep 13, 2006·Journal of Biomedical Optics·Theodore MoffittScott A Prahl
Nov 22, 2008·Journal of Biomedical Optics·Erik AlerstamTomas Svensson
Nov 22, 2008·Journal of Biomedical Optics·Qinghe LiDavid W Allen
May 2, 2009·Journal of Biomedical Optics·David J CucciaBruce J Tromberg
May 2, 2009·Journal of Biomedical Optics·Biju CletusRobert Jordan
Feb 1, 1993·Applied Optics·R GraaffW G Zijistra
Dec 17, 2010·Physics in Medicine and Biology·Paola Di NinniGiovanni Zaccanti
Jan 5, 2011·Optics Express·Paola Di NinniGiovanni Zaccanti
Jan 25, 2011·Biomedical Optics Express·Erik AlerstamLothar Lilge
Aug 13, 2011·Biomedical Optics Express·Paola Di NinniGiovanni Zaccanti
Oct 15, 2011·Optics Express·Michele MartinelliVasan Venugopalan
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
May 24, 2013·Journal of Biomedical Optics·Caigang Zhu, Quan Liu
Apr 22, 2015·Journal of Biomedical Optics·Maciej S WróbelValery V Tuchin
Feb 18, 2016·Journal of Biomedical Optics·William C VogtT Joshua Pfefer
Mar 10, 2016·Evolutionary Computation·Mohammad Reza Bonyadi, Zbigniew Michalewicz
Jul 21, 2017·Journal of Biomedical Optics·Gordon T KennedyAnthony J Durkin

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