Algorithms for a closed-loop artificial pancreas: the case for proportional-integral-derivative control

Journal of Diabetes Science and Technology
Garry M Steil

Abstract

Closed-loop insulin delivery continues to be one of most promising strategies for achieving near-normal control of blood glucose levels in individuals with diabetes. Of the many components that need to work well for the artificial pancreas to be advanced into routine use, the algorithm used to calculate insulin delivery has received a substantial amount of attention. Most of that attention has focused on the relative merits of proportional-integral-derivative versus model-predictive control. A meta-analysis of the clinical data obtained in studies performed to date with these approaches is conducted here, with the objective of determining if there is a trend for one approach to be performing better than the other approach. Challenges associated with implementing each approach are reviewed with the objective of determining how these approaches might be improved. Results of the meta-analysis, which focused predominantly on the breakfast meal response, suggest that to date, the two approaches have performed similarly. However, uncontrolled variables among the various studies, and the possibility that future improvements could still be effected in either approach, limit the validity of this conclusion. It is suggested that a more d...Continue Reading

Associated Clinical Trials

Nov 24, 2014·Michael Agus, Michael Agus

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Citations

Apr 15, 2014·Annals of the New York Academy of Sciences·Thomas PeyserJay S Skyler
Dec 20, 2013·Journal of Diabetes Science and Technology·B Wayne Bequette
Jul 25, 2019·Journal of Diabetes Science and Technology·Emilia FushimiRicardo Sánchez-Peña
Oct 15, 2019·Journal of Diabetes Science and Technology·Lorenzo MeneghettiSimone Del Favero
Jun 18, 2020·Frontiers in Bioengineering and Biotechnology·Fabrizio AngaroniMarco Antoniotti
Aug 3, 2017·Diabetes Technology & Therapeutics·Faye M CameronB Wayne Bequette
Aug 3, 2018·Medical & Biological Engineering & Computing·Saeid BahremandGuim Kwon
Feb 21, 2019·Diabetes Technology & Therapeutics·Alon Liberman, Katharine Barnard
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Oct 15, 2019·Journal of Diabetes Science and Technology·Pau HerreroPantelis Georgiou
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