Mar 10, 2014

Small Molecule Modulation of Microbiome Ecosystem: A Systems Pharmacology Perspective

BioRxiv : the Preprint Server for Biology
Dent EarlBenedict Paten

Abstract

An increasing body of evidence suggests that microbes are not only strongly associated with many human diseases but also responsible for the efficacy, resistance, and toxicity of drugs. Small-molecule drugs which can precisely fine-tune the microbial ecosystem on the basis of individual patients may revolutionize biomedicine. However, emerging endeavors in small-molecule microbiome drug discovery continue to follow a conventional “one-drug-one-target-one-disease” process. It is often insufficient and less successful in tackling complex systematic diseases. A systematic pharmacology approach that intervenes multiple interacting pathogenic species in the microbiome, could offer an attractive alternative solution. Advances in the Human Microbiome Project have provided numerous genomics data to study microbial interactions in the complex microbiome community. Integrating microbiome data with chemical genomics and other biological information enables us to delineate the landscape for the small molecule modulation of the human microbiome network. In this paper, we construct a disease-centric signed microbe-microbe interaction network using metabolite information of microbes and curated microbe effects on human health from published w...Continue Reading

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Mentioned in this Paper

Study
Genome
Whole Genome Amplification
Evaluation
Primates
Nucleotides
Simulation
Analysis
Whole Genome Sequencing
Sequence Alignment

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