Aligned carbon nanotubes on quartz substrate for liquid gated biosensing

Biosensors & Bioelectronics
Al PalaniappanS G Mhaisalkar

Abstract

A facile and high performance biosensing platform using aligned carbon nanotubes on quartz substrate is reported in this communication. Single walled carbon nanotubes are grown on quartz substrates by a chemical vapor deposition process and are characterized with field emission scanning electron microscopy and atomic force microscopy in order to verify the quality of the material. The quartz substrate is then directly used as a biosensor in a field effect transistor configuration. In order to demonstrate the sensing capabilities of the fabricated sensor devices, electronic detection of prostate specific antigen, a potential cancer biomarker, is carried out by adopting liquid gated configuration. A conductivity change due to the specific binding of target antigen with the immobilized receptor antibody demonstrates the sensing capabilities of the fabricated device. Sub-nM detection sensitivities have been obtained using the adopted direct immunoassay approach, which shows that the device responds to clinically relevant concentration regimes.

Citations

Aug 21, 2013·International Journal of Peptides·Steingrimur StefanssonSaeyoung Nate Ahn
Aug 3, 2013·Advanced Drug Delivery Reviews·Sebastian KrussMichael S Strano
Jul 6, 2016·Biomedical Microdevices·Jingfeng HuangAlfred Iing Yoong Tok
Jun 12, 2013·The Analyst·Jianling WangXuemei Wang
Jan 1, 2015·Beilstein Journal of Nanotechnology·Hari Krishna Salila Vijayalal MohanLianxi Zheng
Sep 28, 2017·Bioengineering·Hu ChenAlfred Iing Yoong Tok
Jun 4, 2011·Small·Matthew S Makowski, Albena Ivanisevic
Jan 29, 2014·Accounts of Chemical Research·Bin MuMichael S Strano

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