Alignment for comprehensive two-dimensional gas chromatography with dual secondary columns and detectors

Analytical Chemistry
Stephen E ReichenbachChiara Cordero

Abstract

In each sample run, comprehensive two-dimensional gas chromatography with dual secondary columns and detectors (GC × 2GC) provides complementary information in two chromatograms generated by its two detectors. For example, a flame ionization detector (FID) produces data that is especially effective for quantification and a mass spectrometer (MS) produces data that is especially useful for chemical-structure elucidation and compound identification. The greater information capacity of two detectors is most useful for difficult analyses, such as metabolomics, but using the joint information offered by the two complex two-dimensional chromatograms requires data fusion. In the case that the second columns are equivalent but flow conditions vary (e.g., related to the operative pressure of their different detectors), data fusion can be accomplished by aligning the chromatographic data and/or chromatographic features such as peaks and retention-time windows. Chromatographic alignment requires a mapping from the retention times of one chromatogram to the retention times of the other chromatogram. This paper considers general issues and experimental performance for global two-dimensional mapping functions to align pairs of GC × 2GC chrom...Continue Reading

References

Sep 1, 2005·Journal of Chromatography. a·Mingtian NiEdward B Ledford
May 29, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Qi ZhangA Jiye
Mar 21, 2008·Analytical Chemistry·Dabao ZhangMin Zhang
Oct 23, 2012·Analytical Chemistry·Jonas GrosJ Samuel Arey

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Citations

Oct 19, 2016·Analytical Chemistry·Davis W RempeCláudia Alcaraz Zini
Jan 24, 2017·Journal of Agricultural and Food Chemistry·Chiara CorderoCarlo Bicchi
Aug 24, 2016·The Analyst·Ewa SzymańskaLutgarde M C Buydens
Jan 11, 2020·Critical Reviews in Analytical Chemistry·John Mommers, Sjoerd van der Wal

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