Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites

The Journal of Allergy and Clinical Immunology
Seema S AcevesConsortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

Abstract

Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P < .001). PedsQL-EoE reports correlated between parents and children across ages and multiple domains (r = 0.48-0.79, P < .001). There was a tight correlation between symptoms on PEESSv2.0 and their effects on QOL both on self-report and parental report (P < .001). Self-reported symptoms on PEESSv2.0 (positively) and PedsQL-EoE (inversely) s...Continue Reading

References

Jan 31, 2009·Journal of Pediatric Gastroenterology and Nutrition·Scott PentiukMarc E Rothenberg
Nov 26, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Seema S AcevesRanjan Dohil
Apr 12, 2011·The Journal of Allergy and Clinical Immunology·Chris A LiacourasSeema S Aceves
Jun 26, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evan S Dellon
Mar 13, 2013·Journal of Pediatric Gastroenterology and Nutrition·James P FranciosiJames W Varni
Nov 28, 2013·Gastrointestinal Endoscopy·Evan S DellonNicholas J Shaheen
Dec 24, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·I-Chan HuangCarolyn E Schwartz
Mar 8, 2014·Digestive Diseases·Seema S Aceves
Jun 29, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent MukkadaNicholas J Shaheen
Oct 20, 2017·Journal of Pediatric Psychology·Mary K LynchBurel R Goodin
May 8, 2018·The Lancet. Gastroenterology & Hepatology·Tetsuo ShodaUNKNOWN Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

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Citations

Feb 2, 2019·Current Treatment Options in Gastroenterology·Quan M Nhu, Fouad J Moawad
Jan 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Margaret H CollinsMarc E Rothenberg
Nov 21, 2020·Journal of Pediatric Psychology·Nicole HannanAmie Steel
Jan 26, 2021·Digestive Diseases and Sciences·Nicole ChangEvan S Dellon
Jan 9, 2020·The Journal of Allergy and Clinical Immunology·Nirmala P Gonsalves, Seema S Aceves
Apr 28, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matthew A RankUNKNOWN Joint Task Force on Allergy-Immunology Practice Parameters collaborators
Jul 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Girish HiremathEvan S Dellon
Jul 10, 2021·The Journal of Allergy and Clinical Immunology·UNKNOWN COREOS Collaborators:Ekaterina Safroneeva
Nov 20, 2021·The American Journal of Gastroenterology·Christopher MaEvan S Dellon
Dec 22, 2021·The American Journal of Gastroenterology·Girish HiremathEvan S Dellon

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