Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation

A BröijersénP Hjemdahl


The present study was conducted to determine whether alimentary lipemia alters platelet activity in vivo. Normolipidemic volunteers were given a fatty meal and platelet function was assessed before, and 3 and 6 h after the meal. Platelet aggregability and secretion was determined using whole blood flow cytometry (expression of platelet P-selectin and fibrinogen binding), filtragometry ex vivo (reflecting platelet aggregability in vivo) and by measurements of platelet specific products in plasma (beta-thromboglobulin and platelet factor 4). Plasma triglycerides increased from 0.8 (0.6:1.1; median, 25th and 75th percentiles) to 1.7 (1.0:2.3) mmol/l at 3 h and returned to baseline after 6 h (P < 0.001, one-way ANOVA). Apo B-100 and apo B-48 were both markedly increased 3 h postprandially in the Sf 60-400 fraction (large VLDLs, P < 0.001 for both), whereas the Sf 20-60 (small VLDLs) and Sf 12-20 fractions (IDL) did not change. The platelet function assessments revealed that the percentage of platelets expressing P-selectin increased by 40% (5%; 64%) after 3 h and by 51% (- 7%; 85%) 6 h postprandially in unstimulated samples (P < 0.05 for both). In samples stimulated by ADP in vitro P-selectin expression increased by 45% (6%; 58%) a...Continue Reading


Sep 1, 1979·Circulation·D B Zilversmit
Dec 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S BisovskyH Sinzinger
Nov 11, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J R PatschW Patsch
Feb 1, 1991·The Journal of Cell Biology·K D PatelT M McIntyre
Apr 1, 1991·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A H Goodall
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P H GrootL Havekes
Dec 1, 1990·Atherosclerosis·H S SimpsonJ Shepherd
Jul 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J NimpfG M Kostner
Sep 15, 1985·Thrombosis Research·J A JakubowskiF J Morgan
Jan 1, 1973·Journal of Clinical Pathology. Supplement (Association of Clinical Pathologists)·K Carlson
Nov 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·M J Fletcher
Oct 1, 1984·European Journal of Clinical Investigation·A NordøyS Renaud
Jul 15, 1982·Thrombosis Research·R V JohnstonC R Prentice
Mar 1, 1994·British Journal of Haematology·S L JanesA H Goodall
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·A CeliB Furie
Aug 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·A WeidtmannW Siess
Jun 1, 1995·Current Opinion in Lipidology·F Karpe, A Hamsten
Nov 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M LechleitnerJ R Patsch
Mar 1, 1994·Atherosclerosis·F KarpeA Hamsten
Oct 15, 1993·Biochemical and Biophysical Research Communications·O BeckP Hjemdahl
Jan 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A SilveiraA Hamsten
Mar 1, 1993·The Journal of Clinical Investigation·F KarpeA Hamsten
Jul 1, 1963·Journal of Atherosclerosis Research·L A CARLSON

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