PMID: 6109990Feb 14, 1981Paper

Alinidine reduces heart-rate without blockade of beta-adrenoceptors

Lancet
D W HarronR G Shanks

Abstract

Alinidine is a new drug which reduces heart-rate in animals by an unknown mechanism. Oral administration of 40 and 80 mg significantly reduced an exercise tachycardia in healthy people, with small reductions in heart-rate in the standing and supine positions. Alinidine 80 mg reduced arterial pressure in the standing and supine positions. The reduction in exercise tachycardia produced by 80 mg alinidine was similar to that after 40 mg propranolol, but alinidine had no effect on an isoprenaline tachycardia. These observations indicate that alinidine reduces heart-rate without blocking beta-adrenoceptors and may be useful in patients with angina and in patients with tachyarrhythmias.

Citations

Jan 1, 1982·European Journal of Clinical Pharmacology·J AuböckE Olbrich
Jan 1, 1982·European Journal of Clinical Pharmacology·J SchurmansH De Geest
Jan 1, 1981·European Journal of Clinical Pharmacology·D ArndtsH Justus
Jan 1, 1981·European Journal of Drug Metabolism and Pharmacokinetics·D ArndtsH J Förster
Oct 14, 1986·European Journal of Pharmacology·G KrumplG Raberger
Sep 1, 1981·Journal of Pharmacological Methods·D Arndts, H Stähle
Aug 1, 1987·Journal of Cardiothoracic Anesthesia·E BenjaminT J Iberti
Dec 19, 2006·Pain Practice : the Official Journal of World Institute of Pain·Sean M BrownSandra R Chaplan
Nov 1, 1988·Acta Anaesthesiologica Scandinavica·H GombotzP Rehak
Dec 1, 1983·British Journal of Clinical Pharmacology·J HilaireM Theron
Jan 1, 1983·British Journal of Clinical Pharmacology·D P NichollsR G Shanks
Jun 1, 1982·British Journal of Clinical Pharmacology·D W HarronR G Shanks
Jan 15, 1987·Klinische Wochenschrift·R SchräderM Kaltenbach

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