"Alive" dyes as fluorescent sensors: fluorophore, mechanism, receptor and images in living cells

Chemical Communications : Chem Comm
Xuhong QianWeipin Zhu


In this feature article, we report our recent progresses in fluorescent sensors of biological dyes from the viewpoint of supramolecular and bioorganic chemistry. For signalling fluorophores, we extended or created naphthalene-based ICT systems, e.g. amino-1,8-naphthalimides, amino-1,8-dicyanonaphthalenes and acenaphthopyrrol-9-carbonitriles. We also developed BODIPY derivatives with large Stokes shifts and high fluorescence quantum yields in polar solvents, and a rhodamine analogue working in strong competitive aqueous solution as well as its silaanthracene analogue with a bathochromic shift as large as 90 nm. For sensing mechanisms, we extended or developed the following methods to improve sensing: e.g. PET in a photogenerated electronic field, TICT promoted PET derived from aminoalkyl or piperazino aminonaphthalimides, and the translation/amplification effect of surfactant micelles or aggregation on fluorescent sensing. We also successfully designed deprotonation strengthened ICT, FRET-chemodosimeter sensing systems. For non-cyclic recognition receptors, naphthalimides with two or more side chains at their 4,5- or 3,4-positions, as a convenient and simple platform for ratiometric sensors, were created for the recognition of h...Continue Reading


Jan 1, 1989·Annual Review of Neuroscience·R Y Tsien
Dec 9, 1994·Journal of Medicinal Chemistry·R J HodgkissM R Stratford
Oct 18, 2001·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·J Arden-JacobK H Drexhage
Jan 31, 2002·Journal of the American Chemical Society·Kyle R GeeRobert Kennedy
Aug 5, 1997·Chemical Reviews·A. Prasanna de SilvaTerence E. Rice
Feb 6, 2003·Journal of the American Chemical Society·Huarui HeJames K Tusa
Feb 26, 2004·Journal of the American Chemical Society·Xiangfeng GuoLihua Jia
May 13, 2004·Chemical Reviews·George W GokelMichelle E Weber
Apr 14, 2005·Chemical Reviews·Dennis M VriezemaRoeland J M Nolte
Dec 20, 2005·Chemical Research in Toxicology·Zhichao ZhangZhe Feng
Mar 9, 2006·Journal of the American Chemical Society·Arabinda MallickNitin Chattopadhyay
Aug 31, 2006·Journal of the American Chemical Society·Prakash P NeelakandanDanaboyina Ramaiah
Nov 2, 2006·Journal of the American Chemical Society·Mi Hee LimStephen J Lippard
Jun 22, 2007·Angewandte Chemie·Zhiqian GuoHe Tian
Aug 4, 2007·Journal of the American Chemical Society·Meng ZhangChunhui Huang
Oct 11, 2007·Chemical Reviews·Aurore Loudet, Kevin Burgess
Dec 15, 2007·Organic Letters·Min Hee LeeJong Seung Kim
Dec 28, 2007·Bioorganic & Medicinal Chemistry·Weiping ZhuXuhong Qian
Apr 23, 2008·Chemical Reviews·Emily L QueChristopher J Chang
Apr 25, 2008·Journal of the American Chemical Society·Juan TolosaUwe H F Bunz
Jul 18, 2008·Chemical Communications : Chem Comm·Zhiguo ZhouChunhui Huang
Jul 26, 2008·Chemical Reviews·Elizabeth M Nolan, Stephen J Lippard
Aug 15, 2008·Journal of the American Chemical Society·Akio OjidaItaru Hamachi
Aug 16, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Junhong QianShenyi Zhang
Sep 17, 2008·Angewandte Chemie·Xiaolin ZhangXuhong Qian
Sep 20, 2008·Chemical Communications : Chem Comm·Junhong QianShenyi Zhang

❮ Previous
Next ❯


Feb 16, 2013·Chemical Reviews·Anthony S StenderNing Fang
Apr 7, 2011·Chemical Communications : Chem Comm·Yael AbrahamYoav Eichen
Dec 14, 2011·Sensors·Florian V EnglichTanya M Monro
Dec 3, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·P S Hariharan, Savarimuthu Philip Anthony
Jan 23, 2016·Scientific Reports·Jiangli FanXiaojun Peng
Mar 5, 2016·Luminescence : the Journal of Biological and Chemical Luminescence·Xiaohong ChengGuijie Liang
May 13, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shuai XuRui Yan
Aug 2, 2015·Journal of Colloid and Interface Science·Chunsheng HeXuhong Qian
Jul 3, 2013·Biosensors & Bioelectronics·Ji Young ChoiJuyoung Yoon
May 23, 2014·Chemistry : a European Journal·Sanjoy Mukherjee, Pakkirisamy Thilagar
Jun 9, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Kadarkaraisamy MariappanAndrew G Sykes
May 9, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Shenyi ZhangXuhong Qian
Mar 1, 2016·Chemical Communications : Chem Comm·Robert B P Elmes
Nov 28, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Lin XuHai-Bo Yang
Feb 7, 2015·Chemical Communications : Chem Comm·Xiaobiao DongDeqing Zhang
Feb 20, 2015·Chemical Society Reviews·Brian DalyA Prasanna de Silva
Jan 20, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Yasuhiro KubotaMasaki Matsui
Aug 1, 2015·Chemical Science·Jue LingA Prasanna de Silva
Jan 17, 2015·Organic & Biomolecular Chemistry·Vellanki LakshmiMangalampalli Ravikanth
Mar 11, 2015·Chemical Communications : Chem Comm·Mitsumasa HommaShinji Takeoka
Aug 23, 2017·Organic & Biomolecular Chemistry·Sankarasekaran ShanmugarajuThorfinnur Gunnlaugsson
Jul 26, 2018·Scientia pharmaceutica·Justyna Żwawiak, Lucjusz Zaprutko

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.