ALK -rearrangement neuroendocrine carcinoma of the lung: a comprehensive study of a rare case series and review of literature

OncoTargets and Therapy
Qiang ZhengYuan Li

Abstract

Driver mutations involving tyrosine kinase receptors play crucial roles in the oncogenesis of lung adenocarcinoma. However, receptor tyrosine kinase mutations are extremely rare events in primary pulmonary neuroendocrine carcinoma (NEC), which is a molecular heterogeneous entity. In this study, we examined 4 cases of NEC with anaplastic lymphoma kinase (ALK) rearrangement between 2008 and 2018 at our hospital. We comprehensively analyzed the carcinomas' clinicopathological features, genetic alterations, and response to ALK inhibitor. One case of atypical carcinoid tumor and 1 case of large cell NEC (LCNEC) achieved response to ALK inhibitor (crizotinib) treatment. One case of combined LCNEC with adenocarcinoma harboring KLC1-ALK (K9:A20) fusion genes was confirmed by NGS of both components, while only the LCNEC component presented RB1 mutation. Notably, tumor cells of different components exhibited different ALK-positive signal patterns by fluorescence in situ hybridization, which revealed isolated 3' signals in the adenocarcinoma component but split signals in the LCNEC. As the largest case series study, our findings suggested that preliminary screening for ALK rearrangement should also be considered in atypical carcinoid and ...Continue Reading

Citations

Nov 7, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Oscar Lopez-NunezLea F Surrey
Sep 29, 2019·Cancer Biology & Therapy·Na LiuYu Yao
Jul 6, 2019·Clinical and Translational Medicine·Mariangela TorniaiRossana Berardi
Jun 7, 2019·Clinical Lung Cancer·Julian PinsolleAnne McLeer-Florin

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

Illumina suite

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