ALK IHC and FISH discordant results in patients with NSCLC and treatment response: for discussion of the question-to treat or not to treat?

ESMO Open
Florian CabillicFabrice Barlesi

Abstract

Lung cancer is the most common cancer worldwide. Latest guidelines from the College of American Pathologist and the European society of medical oncologists indicate anaplastic lymphoma kinase (ALK) rearrangement testing is standard practice. Historically, diagnostics for ALK used fluorescence in situ hybridisation (FISH); however, immunohistochemical (IHC) assays are becoming common practice. Unfortunately, recent assessment of current practice indicated that not all patients who should be tested for ALK translocation are undergoing ALK testing. From a series of European and Israeli labs, we collected patients with discordant IHC and FISH testing, which were subsequently treated with ALK-targeted therapy, for discussion of the question, to treat or not to treat? Our study may support ALK IHC testing as a better predictor of response to targeted therapy provided that the labs implement controlled preanalytical procedures, use correct clone, run protocols on automated staining platforms and validate using external quality assessments.

References

Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Scott J RodigLucian R Chirieac
Aug 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nir PeledVincent A Miller
Apr 12, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Murry W WynesFred R Hirsch
Dec 4, 2014·The New England Journal of Medicine·Benjamin J SolomonUNKNOWN PROFILE 1014 Investigators
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Citations

Nov 15, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Eunhyang Park, Hyo Sup Shim
Oct 28, 2019·Cancer Medicine·Gaëlle TachonLucie Karayan-Tapon
Dec 19, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tony MokAlice T Shaw
Mar 24, 2021·Journal of Clinical Pathology·Ullas BatraAnurag Mehta
Jul 27, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sebastian MondacaBob T Li

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Methods Mentioned

BETA
Assay

Software Mentioned

Ventana

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