ALK-rearranged renal cell carcinomas in children

Genes, Chromosomes & Cancer
Mariana M CajaibaElizabeth J Perlman

Abstract

Knowledge of the clinicopathological and molecular spectrum of pediatric renal cell carcinomas (RCC) remains limited, and approximately 16%-24% of these neoplasms cannot be classified into specific subtypes. In this review of 168 pediatric RCC prospectively registered on Children's Oncology Group AREN03B2 protocol, six RCC (3.5%) that demonstrated a unique epithelioid morphology and a peculiar immunophenotypic profile that includes expression of ALK, TFE3, and retention of INI1 was identified. Further investigation revealed ALK rearrangements in all cases, manifested molecularly by fusion transcripts of either VCL-ALK (3 patients all with sickle cell trait which had been previously reported) or TPM3-ALK (3 patients, none with sickle cell trait). Based on the shared unique morphologic, immunophenotypic, and genetic features, it was proposed that these neoplasms belonged to a distinct subgroup of RCC frequently occurring in pediatric patients, which they have termed as ALK-rearranged RCC. Importantly, additional therapeutic options may be available for these patients.

References

Jan 5, 2000·Kidney International·P T PhamS Q Lew
Mar 8, 2000·American Journal of Hematology·K I Ataga, E P Orringer
Aug 10, 2000·The American Journal of Pathology·B LawrenceJ A Fletcher
Oct 26, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·N KurodaH Enzan
Aug 19, 2004·The American Journal of Surgical Pathology·Elisabeth BruderHolger Moch
Aug 9, 2006·Trends in Cell Biology·Wolfgang H ZieglerDavid R Critchley
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Guido PastoreEva Steliarova-Foucher
Feb 6, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Florence ArmstrongChristian Touriol
Jan 16, 2008·Physiological Reviews·Peter GunningEdna Hardeman
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Larisa V DebelenkoJulia A Bridge
Dec 22, 2010·Cell Adhesion & Migration·Justin G LeesGeraldine M O'Neill
Jan 8, 2011·Genes, Chromosomes & Cancer·Adrián Mariño-EnríquezAntonio R Pérez-Atayde
Nov 1, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stephan Macher-GoeppingerSebastian Aulmann
May 18, 2012·Leukemia Research·Saeam ShinKyung-A Lee
Jun 30, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·William R SukovJohn C Cheville
Nov 28, 2012·PloS One·Ashish MisraThirumaran Thanabalu
Dec 4, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
Mar 16, 2013·Cell Biology International·Wolfgang H GoldmannBen Fabry
Sep 13, 2013·The American Journal of Surgical Pathology·Brett DelahuntUNKNOWN Members of the ISUP Renal Tumor Panel
Apr 5, 2014·The American Journal of Surgical Pathology·Nathaniel E SmithPedram Argani
Nov 25, 2014·International Journal of Hematology·Akihiro HoshinoHirokazu Kanegane
Jan 18, 2015·Biochemical and Biophysical Research Communications·Yosuke AmanoDaiya Takai

❮ Previous
Next ❯

Citations

Aug 25, 2016·Pathology, Research and Practice·Marie JeanneauXavier Leroy
Oct 18, 2016·Pediatric Blood & Cancer·Samara L PotterD Williams Parsons
Nov 4, 2016·Expert Review of Anticancer Therapy·Srividya SrinivasamaharajCesar A Perez
Dec 31, 2016·International Journal of Molecular Sciences·Brittany M SalazarShizhen Zhu
Oct 21, 2017·International Journal of Molecular Sciences·Kentaro Inamura
Jan 13, 2018·The American Journal of Dermatopathology·Dmitry V KazakovMichal Michal
Jun 8, 2018·The American Journal of Surgical Pathology·Alison L CheahJohn R Goldblum
Aug 2, 2017·Cancer Science·Junko Takita
Dec 20, 2018·Histopathology·Kiril Trpkov, Ondřej Hes
May 30, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Naoto KurodaOndrej Hes
Dec 24, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kenneth Tou En ChangChung W Chow
Jan 30, 2020·Virchows Archiv : an International Journal of Pathology·Jen-Fan HangChin-Chen Pan
Jan 8, 2020·Cancers·Reza AlaghehbandanOndrej Hes
Nov 26, 2020·Virchows Archiv : an International Journal of Pathology·Hanna MajewskaWojciech Biernat
Feb 3, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril TrpkovOndrej Hes
Aug 26, 2020·Archives of Medical Research·Maria S Tretiakova
Jan 7, 2021·Archives of Pathology & Laboratory Medicine·Nicholas BaniakMichelle S Hirsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved