PMID: 1202241Dec 11, 1975Paper

Alkali lability of bacteriophage phi W-14 DNA

Journal of Virology
H A LewisR A Warren

Abstract

The molecular weight of bacteriophage phi W-14 DNA, determined by velocity sedimentation in neutral sucrose gradients, was 92 +/- 6 X 10(6). The DNA showed marked fragmentation in alkaline sucrose gradients. This fragmentation was not a consequence of preexisting single-strand interruptions in the DNA, since thermal denaturation of DNA yielded intact single strands. The alpha-putrescinylthymine groups in phi W-14 DNA appeared to be labile; some, or parts of some, of these groups were cleaved from the DNA in alkali.

References

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Citations

Apr 1, 1984·Biopolymers·J WilcoxonR A Warren
Jan 1, 1984·Molecular & General Genetics : MGG·P LopezR A Warren
Feb 1, 1982·Journal of Bacteriology·P LopezR A Warren
Mar 8, 1985·Biochimica Et Biophysica Acta·S SpetterS Hanlon

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