Alkali production associated with malolactic fermentation by oral streptococci and protection against acid, oxidative, or starvation damage.

Canadian Journal of Microbiology
Jiangyun ShengR E Marquis

Abstract

Alkali production by oral streptococci is considered important for dental plaque ecology and caries moderation. Recently, malolactic fermentation (MLF) was identified as a major system for alkali production by oral streptococci, including Streptococcus mutans. Our major objectives in the work described in this paper were to further define the physiology and genetics of MLF of oral streptococci and its roles in protection against metabolic stress damage. L-Malic acid was rapidly fermented to L-lactic acid and CO(2) by induced cells of wild-type S. mutans, but not by deletion mutants for mleS (malolactic enzyme) or mleP (malate permease). Mutants for mleR (the contiguous regulator gene) had intermediate capacities for MLF. Loss of capacity to catalyze MLF resulted in loss of capacity for protection against lethal acidification. MLF was also found to be protective against oxidative and starvation damage. The capacity of S. mutans to produce alkali from malate was greater than its capacity to produce acid from glycolysis at low pH values of 4 or 5. MLF acted additively with the arginine deiminase system for alkali production by Streptococcus sanguinis, but not with urease of Streptococcus salivarius. Malolactic fermentation is clea...Continue Reading

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Citations

Dec 12, 2012·Odontology·William H Bowen
Jun 4, 2011·Canadian Journal of Microbiology·Zhang LeiYu Yongxiong
Dec 1, 2015·Food Chemistry·Riitta Puupponen-PimiäKirsi-Marja Oksman-Caldentey
Jul 15, 2015·Molecular Oral Microbiology·J P Bitoun, Z T Wen
May 26, 2012·Microbiology·Matthew E MacGilvrayRobert G Quivey
Oct 25, 2016·Molecular Oral Microbiology·J L BakerR G Quivey
Sep 18, 2015·Journal of Dental Research·N Takahashi
Jan 15, 2015·Infection and Immunity·Elyse Paluscio, Michael G Caparon
Jul 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·Konstantinos PapadimitriouJan Kok
Jul 3, 2021·International Journal of Environmental Research and Public Health·Maria D FerrerAlejandro Mira

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