PMID: 6588537Jan 1, 1984

Alkali secretion by isolated rabbit gastric mucosa: effects of non-steroidal anti-inflammatory drugs and prostaglandins

Scandinavian Journal of Gastroenterology. Supplement
W D ReesL A Turnberg

Abstract

The effects of aspirin, indomethacin and prostaglandins E2 and F2 alpha on the secretory and electrical activity of isolated rabbit gastric mucosa have been studied. Serosal side application of indomethacin (10(-5) M) or aspirin (3 X 10(-3) M) inhibited alkali secretion by fundic mucosa (mean +/- SE: 0.55 +/- 0.06 to 0.12 +/- 0.06 mumol X cm-2 X h-1, n = 6, p less than 0.01 and 0.28 +/- 0.06 to 0.11 +/- 0.03 mumol X cm-2 X h-1, n = 7, p less than 0.02 respectively) and antral mucosa (0.80 +/- 0.03 to 0.53 +/- 0.21 mumol X cm-2 X h-1, n = 5, p less than 0.01 and 0.75 +/- 0.23 to 0.47 +/- 0.20 mumol X cm-2 X h-1, n = 8, p less than 0.01 respectively). Mucosal and serosal side application of prostaglandin E2 or F2 alpha (10(-10) to 10(-4) M) had no effect on gastric alkali secretion. Serosal side 16,16 dimethyl E2 (10(-6) M) stimulated alkali secretion by fundic mucosa (0.90 +/- 0.20 to 1.50 +/- 0.30 mumol X cm-2 X h-1, n = 6, p less than 0.01) and abolished the inhibition of alkali production caused by indomethacin in fundic and antral mucosae. Inhibition of alkali secretion by aspirin was not modified by 16,16 dimethyl E2 pretreatment. The findings suggest that mucosal damage by aspirin and indomethacin may be mediated by inhibi...Continue Reading

Related Concepts

Alkalies
Anti-Inflammatory Agents
Zorprin
Structure of Pyloric Gland
Hydrogen-Ion Concentration
Osmosin
Prostaglandins
Prostaglandins E
Prostaglandins F
Prostenon

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